Chloroquine diphosphate, identified by its CAS number 50-63-5, is a synthetic compound whose production involves meticulous chemical synthesis. The primary synthesis route typically involves the reaction of 4,7-dichloroquinoline with 1-diethylamino-4-aminopentane. This process yields chloroquine, which is then converted into its diphosphate salt for enhanced stability and solubility, making it suitable for pharmaceutical formulations. The precise control of reaction conditions, purification techniques, and quality assurance are critical steps in manufacturing this important Active Pharmaceutical Ingredient (API).

The chemical structure of chloroquine diphosphate imparts its characteristic properties. Its molecular formula is C18H26ClN3·2H3PO4, with a molecular weight of approximately 515.865 g/mol. In its pure form, it appears as a white crystalline powder. Understanding the chloroquine diphosphate chemical synthesis is vital for manufacturers to ensure the purity and efficacy of the final product. Companies like NINGBO INNO PHARMCHEM CO.,LTD. invest heavily in R&D to optimize these processes.

The physical and chemical properties of chloroquine diphosphate are essential for its various applications. While its solubility in water is moderate, its stability as a diphosphate salt is advantageous for storage and formulation. The purity of the compound is a key factor, particularly when it is used as a pharmaceutical intermediate or API. Manufacturers adhere to stringent quality control measures, often including HPLC analysis, to confirm purity levels, typically exceeding 99%.

For researchers and pharmaceutical companies looking to buy chloroquine diphosphate, sourcing from reliable manufacturers is crucial. The availability of detailed technical data, including Certificates of Analysis (CoA), is standard practice. These documents provide information on purity, assay methods, and other critical parameters, ensuring the material meets the required specifications for its intended use. The consistent price of chloroquine diphosphate can vary based on purity, quantity, and supplier, making informed purchasing decisions important.

The production of high-quality chloroquine diphosphate is a testament to advancements in chemical synthesis and pharmaceutical manufacturing. Its journey from raw materials to a finished pharmaceutical ingredient highlights the complexity and precision involved in bringing essential medicines to the market.