Citicoline Sodium, a crucial compound with the CAS number 33818-15-4, is a cornerstone in both the pharmaceutical and nutraceutical industries. Understanding its chemical properties and ensuring the procurement of high-quality Active Pharmaceutical Ingredient (API) are paramount for its effective application. This article provides an in-depth look at the chemical nature of Citicoline Sodium and guides on sourcing practices.

Chemically, Citicoline Sodium is the monosodium salt of cytidine diphosphate-choline. It typically presents as a white crystalline powder, odorless, and is freely soluble in water, while being insoluble in organic solvents like ethanol and acetone. This solubility profile is advantageous for various formulations, particularly those requiring aqueous solutions.

The molecular formula for Citicoline Sodium is C14H25N4NaO11P2, with a molecular weight of approximately 510.31 g/mol. Its structure includes cytosine, ribose, phosphate, and choline moieties, all linked in a specific arrangement that is key to its biological activity. As an intermediate in the synthesis of phosphatidylcholine, it directly contributes to the structural integrity of cell membranes.

In terms of quality standards, Citicoline Sodium API is often required to meet stringent specifications, with purity levels typically exceeding 99%. Certifications such as USP (United States Pharmacopeia), BP (British Pharmacopoeia), and EP (European Pharmacopoeia) are common indicators of quality and compliance. Manufacturers adhering to GMP (Good Manufacturing Practices) are essential for ensuring the consistent production of high-grade Citicoline Sodium.

Sourcing high-quality Citicoline Sodium involves several key considerations. Prospective buyers should look for suppliers who can provide comprehensive documentation, including Certificates of Analysis (CoA), Material Safety Data Sheets (MSDS), and details on their manufacturing processes. Verifying that the supplier has robust quality control systems and adherence to international regulatory standards is crucial.

Many reputable manufacturers based in China and India specialize in producing pharmaceutical-grade Citicoline Sodium, offering it in various bulk quantities. When evaluating suppliers, factors like production capacity, delivery timelines, and customer service should also be taken into account. The competitive pricing often associated with sourcing from these regions makes it an attractive option for global pharmaceutical companies.

In summary, Citicoline Sodium is a compound characterized by its white crystalline appearance, excellent water solubility, and high purity. Its vital role in brain health and neurological support necessitates careful attention to sourcing practices. By prioritizing suppliers with strong quality assurances and adherence to international standards, businesses can secure reliable access to this essential pharmaceutical intermediate.