Tigecycline (CAS 220620-09-7) is a potent antibiotic that requires careful management by pharmacists to ensure optimal patient outcomes and safety. As a glycylcycline, its unique tigecycline mechanism of action targets bacterial protein synthesis, offering a broad tigecycline antibacterial spectrum against many resistant pathogens. This makes it a valuable agent for specific indications like complicated skin and soft tissue infections (cSSTI) and complicated intra-abdominal infections (cIAI).

Pharmacists play a crucial role in monitoring for tigecycline side effects, which can include gastrointestinal upset and injection site reactions. Equally important is the awareness of tigecycline drug interactions. For instance, Tigecycline may interact with warfarin, requiring close monitoring of INR, and potentially affect the efficacy of oral contraceptives. Dosing adjustments may be necessary in cases of severe hepatic impairment, highlighting the importance of reviewing patient comorbidities when considering tigecycline administration.

The tigecycline black box warning, which addresses an increased risk of mortality, mandates that pharmacists ensure Tigecycline is used only when no other suitable alternatives are available. Understanding the underlying tigecycline resistance mechanisms helps in appreciating its role as a reserve agent. Clinical pearls for pharmacists include emphasizing proper reconstitution and infusion times, as well as educating patients on potential adverse effects and the importance of completing the full course of therapy, even if symptoms improve.

NINGBO INNO PHARMCHEM CO.,LTD. provides Tigecycline, a critical component in the pharmacopeia for managing severe bacterial infections, and supports pharmacists in their role of ensuring its safe and effective use.