Understanding the scientific underpinnings of Ivermectin is crucial for appreciating its efficacy as a pharmaceutical intermediate. NINGBO INNO PHARMCHEM CO.,LTD. provides high-purity Ivermectin powder (CAS 70288-86-7) that adheres to strict quality standards, reflecting its complex yet elegant chemical nature and its targeted mechanism of action.

Ivermectin belongs to the avermectin class of compounds, which are macrocyclic lactones. Chemically, it is derived from Streptomyces avermitilis and is a mixture of at least 80% 22,23-dihydroavermectin B1a and no more than 20% 22,23-dihydroavermectin B1b. Its molecular formula is C48H74O14 for B1a and C47H72O14 for B1b, with a molecular weight of approximately 875.09300 g/mol. The typical appearance is a white to yellowish-white crystalline powder, confirming the quality of the high purity ivermectin bulk we supply.

The primary mechanism of action for Ivermectin involves its interaction with glutamate-gated chloride channels (GluCls) and, to a lesser extent, GABA receptors, which are crucial for nerve and muscle function in invertebrates. By binding to these channels, Ivermectin increases the permeability of the cell membrane to chloride ions. This influx of ions leads to hyperpolarization of the nerve and muscle cells, resulting in paralysis and eventual death of the target parasites. Importantly, mammals have different chloride channels, and Ivermectin's ability to cross the blood-brain barrier is limited at therapeutic doses, contributing to its favorable safety profile in humans and animals.

This precise interaction with invertebrate-specific channels makes Ivermectin a powerful and targeted antiparasitic drug wholesale. Pharmaceutical manufacturers rely on the consistent quality and chemical integrity of GMP grade ivermectin powder to ensure the effectiveness of their finished products. NINGBO INNO PHARMCHEM CO.,LTD. is committed to supplying this vital chemical synthesis intermediate with the utmost attention to purity and quality, enabling critical advancements in both veterinary and human medicine.