At NINGBO INNO PHARMCHEM CO.,LTD., we are committed to providing deep insights into the pharmaceuticals we offer. Today, we focus on Afatinib, a vital component in targeted cancer therapy, particularly for non-small cell lung carcinoma (NSCLC). Understanding its pharmacokinetic profile is paramount for effective and safe usage.

Afatinib, an irreversible ErbB family blocker, is administered orally. Its absorption is influenced by food; intake should ideally occur at least one hour before or two to three hours after meals to ensure optimal bioavailability. Maximum plasma concentrations are typically reached within 2-5 hours post-administration.

A key aspect of Afatinib's pharmacokinetic profile is its metabolism and elimination. Unlike many drugs, Afatinib undergoes minimal metabolism. The parent compound is predominantly excreted unchanged, primarily through feces (around 85%) and a small fraction in urine (about 5%). This characteristic is significant as it suggests a reduced likelihood of interactions with cytochrome P450 (CYP) enzyme-mediated pathways, a common source of drug-drug interactions.

The effective elimination half-life of Afatinib is approximately 37 hours. This extended half-life supports a once-daily dosing regimen, contributing to patient convenience and compliance. Accumulation of the drug occurs with multiple dosing, as expected, but the pharmacokinetic profile remains consistent across various patient populations.

NINGBO INNO PHARMCHEM CO.,LTD. emphasizes that while Afatinib's pharmacokinetics are generally predictable, certain factors can influence exposure. These include renal function and body weight. Females and individuals with lower body weight may experience slightly increased exposure. However, the influence of age, ethnicity, smoking status, and hepatic function on Afatinib's pharmacokinetics is minimal.

For professionals seeking high-quality Afatinib, NINGBO INNO PHARMCHEM CO.,LTD. offers reliable sourcing. We understand the importance of consistent product quality and supply chain integrity for pharmaceutical research and development. Explore our offerings to learn more about how we can support your needs in advance pharmaceutical chemicals.