Domperidone, bearing the CAS number 57808-66-9, is a critical active pharmaceutical ingredient (API) widely utilized for its antiemetic and gastroprokinetic properties. As a selective dopamine D2 receptor antagonist, it operates primarily in the periphery, which is key to its therapeutic profile in managing gastrointestinal ailments.

The primary application of Domperidone is in alleviating symptoms of nausea and vomiting. It achieves this by blocking dopamine receptors in the chemoreceptor trigger zone, a part of the brainstem that plays a central role in the emetic reflex. This targeted action helps to quickly quell feelings of sickness and the urge to vomit, offering much-needed relief to patients experiencing these symptoms.

Furthermore, Domperidone is instrumental in treating conditions characterized by impaired gastric motility, such as gastroparesis. By enhancing the contractility of the stomach and intestines, it helps to accelerate the passage of food through the digestive tract. This improved motility can alleviate symptoms like early satiety, bloating, and abdominal discomfort, significantly improving a patient's quality of life. The demand for Domperidone API from reliable Domperidone manufacturers ensures a steady supply of this crucial medication.

When considering Domperidone for nausea and vomiting, understanding its pharmacokinetics is important. It is absorbed orally, though with low bioavailability due to extensive first-pass metabolism. Its half-life is approximately 7-9 hours, allowing for effective symptom management with appropriate dosing. For those looking to purchase Domperidone, ensuring the product meets stringent Domperidone purity standards is paramount, as it directly relates to its therapeutic efficacy and safety.

The compound's interaction with dopamine receptors also influences prolactin release, leading to its off-label use as a galactagogue to increase milk supply in breastfeeding mothers. This demonstrates its broad pharmacological impact beyond the GI tract. However, potential users should be aware of reported side effects and consult healthcare providers for guidance, especially regarding its use in lactation or potential drug interactions.

In conclusion, Domperidone (CAS 57808-66-9) is an indispensable API for the pharmaceutical industry. Its efficacy in treating nausea, vomiting, and motility disorders, coupled with its potential for lactation support, underscores its importance. NINGBO INNO PHARMCHEM CO.,LTD. is a key player in providing high-grade Domperidone, ensuring that the needs of researchers and pharmaceutical formulators are met with quality and reliability.