For any chemical intermediate to be effectively utilized in research and industrial applications, a thorough understanding of its properties and proper handling procedures is essential. 1-Bromo-4-(trans-4-butylcyclohexyl)benzene (CAS 516510-78-4) is a sophisticated organic compound used in advanced applications, and knowing its characteristics ensures safety, efficiency, and successful outcomes. This article delves into its key chemical properties, stability considerations, and recommended handling practices, providing valuable insights for professionals working with this compound.

The chemical nature of 1-Bromo-4-(trans-4-butylcyclohexyl)benzene is defined by its structure: a benzene ring substituted with a bromine atom and a trans-4-butylcyclohexyl group. Typically appearing as a white crystalline powder, it possesses a molecular formula of C16H23Br and a molecular weight of approximately 295.26 g/mol. Its purity, often specified as ≥99% by HPLC, is critical for its performance in sensitive applications like liquid crystal formulations and pharmaceutical synthesis. The melting point typically falls within the range of 68-72°C, indicating it is a solid at room temperature.

Key chemical properties include its solubility – it is soluble in ether, THF, and DCM, but only slightly soluble in ethanol. This solubility profile guides solvent selection for reactions and purification processes. The compound's reactivity is largely dictated by the bromine atom, which is amenable to various substitution and cross-coupling reactions, particularly palladium-catalyzed transformations. The trans-4-butylcyclohexyl moiety contributes to its mesomorphic properties and steric bulk, influencing its behavior in different chemical environments.

Stability and storage are crucial considerations for maintaining the integrity of 1-Bromo-4-(trans-4-butylcyclohexyl)benzene. It is recommended to store the compound at 2-8°C in an airtight container under an inert gas. This type of storage helps prevent degradation from moisture, air, or light, which can compromise its purity and reactivity over time. Proper sealing and controlled temperature storage are vital, especially for industrial-scale quantities to ensure a consistent supply of high-quality material.

When handling this chemical, standard laboratory safety practices should always be followed. This includes wearing appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation exposure. While specific hazard data can vary, compounds of this nature may cause skin and eye irritation, and respiratory irritation if inhaled. Consulting the Safety Data Sheet (SDS) provided by the manufacturer, such as NINGBO INNO PHARMCHEM CO.,LTD., is paramount before use. This ensures awareness of potential hazards and the appropriate emergency procedures. For anyone looking to purchase this essential intermediate, understanding these handling guidelines is as important as understanding its synthetic utility.