NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to ensuring the highest standards of quality for the chemical intermediates we supply. For compounds like 2-Chloro-1-cyclopentylethanone (CAS 932-28-5), rigorous analytical characterization is paramount to confirm its identity, purity, and structural integrity. This article outlines the key analytical techniques employed in the research and quality control of this important organic compound.

Nuclear Magnetic Resonance (NMR) spectroscopy is a cornerstone technique for structural elucidation. Both proton (¹H) and carbon (¹³C) NMR provide detailed information about the molecular environment of hydrogen and carbon atoms, respectively. For 2-Chloro-1-cyclopentylethanone, ¹H NMR would reveal characteristic signals for the cyclopentyl ring protons and the methylene protons adjacent to the chlorine atom, while ¹³C NMR would identify the carbonyl carbon and other distinct carbon environments. Advanced 2D NMR techniques, such as COSY and HMBC, can further confirm the connectivity of atoms within the molecule, providing unambiguous structural assignment.

Mass Spectrometry (MS) is crucial for determining the molecular weight and fragmentation pattern of the compound. The molecular formula of 2-Chloro-1-cyclopentylethanone (C₇H₁₁ClO) results in a characteristic isotopic pattern in the mass spectrum due to the presence of chlorine isotopes (³⁵Cl and ³⁷Cl). This signature is vital for confirming the presence and number of chlorine atoms in the molecule. Common fragmentation pathways, such as the loss of the chloromethyl group, are also analyzed to further validate the structure.

Infrared (IR) spectroscopy is employed to identify functional groups. The presence of a strong absorption band in the 1700-1725 cm⁻¹ region of the IR spectrum is indicative of the ketone carbonyl group, while other characteristic bands confirm the presence of C-H and C-Cl bonds. This technique serves as a quick and effective method for functional group verification.

Chromatographic techniques are indispensable for assessing purity and separating components. High-Performance Liquid Chromatography (HPLC), often using a C18 stationary phase and UV detection, is widely used to quantify the purity of 2-Chloro-1-cyclopentylethanone and to detect any impurities, such as unreacted starting materials or byproducts. Gas Chromatography-Mass Spectrometry (GC-MS) is also employed, particularly for volatile samples, combining chromatographic separation with mass spectrometric detection for highly sensitive impurity profiling.

For researchers and manufacturers looking to buy 2-Chloro-1-cyclopentylethanone, ensuring its quality through these rigorous analytical methods is essential. NINGBO INNO PHARMCHEM CO.,LTD. adheres to strict quality control protocols, utilizing these advanced techniques to guarantee that our products meet the highest standards for your critical research and production needs.