NINGBO INNO PHARMCHEM CO.,LTD. is pleased to present N-Boc-p-toluenesulfonamide (CAS: 18303-04-3), also known by synonyms such as N-(tert-Butoxycarbonyl)-p-toluenesulfonamide or tert-Butyl tosylcarbamate. This compound is a highly valued intermediate in the realm of organic synthesis, indispensable for its versatility in facilitating complex chemical transformations.

With the chemical formula C12H17NO4S and a molecular weight of 271.33, N-Boc-p-toluenesulfonamide typically appears as a white to almost white powder. It is characterized by its solubility in chloroform and its stability at room temperature, making it a practical reagent for various laboratory and industrial applications. The tert-butoxycarbonyl (Boc) protecting group on the sulfonamide nitrogen provides a specific reactivity profile that is highly sought after in synthetic organic chemistry.

A cornerstone application of N-Boc-p-toluenesulfonamide is its role as a critical precursor in the Pauson-Khand reaction. This reaction is renowned for its efficiency in constructing cyclopentenone rings, which are vital components in the synthesis of many natural products, pharmaceuticals, and advanced materials. The compound’s participation in this cycloaddition allows for the controlled formation of these cyclic structures, contributing significantly to the efficiency of complex synthetic routes. Chemists often rely on such specialized organic synthesis intermediates to achieve target molecules.

Furthermore, N-Boc-p-toluenesulfonamide is a key reagent in Mitsunobu reactions. This reaction facilitates the direct coupling of alcohols with nitrogen sources, leading to the formation of protected amines. Specifically, it enables the stereoselective conversion of alcohols into sulfonyl-protected amines, a crucial step in many synthetic strategies within pharmaceutical research and development. The ability to introduce amine functionalities efficiently is paramount, and NINGBO INNO PHARMCHEM CO.,LTD. ensures a reliable supply of this reagent.

The compound also finds utility in the preparation of enyne amides, further expanding its synthetic scope. As a versatile building block for chemical synthesis, it supports a wide range of chemical research and industrial production processes. The consistent quality and availability of N-Boc-p-toluenesulfonamide are essential for researchers and manufacturers aiming for reproducible and high-yield results. The understanding of sulfonamide derivatives in synthesis is a growing area of interest.

In conclusion, N-Boc-p-toluenesulfonamide is an indispensable intermediate in modern organic chemistry, particularly valued for its roles in the Pauson-Khand and Mitsunobu reactions. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing this essential chemical, empowering scientific innovation and the development of new chemical entities.