For professionals working with 5-Ethylthio-1H-Tetrazole (ETT), understanding its properties and ensuring safe handling are crucial for successful and secure laboratory operations. This article provides essential information regarding the physical characteristics, chemical behavior, and safety considerations associated with this important compound, often sourced from dedicated suppliers and manufacturers.

Physically, 5-Ethylthio-1H-Tetrazole is typically presented as a white solid. Its molecular formula is C3H6N4S, with a molecular weight of approximately 130.17 g/mol. Like many fine chemical intermediates, its stability and reactivity are key to its utility. ETT is soluble in various solvents, with solubility data available from chemical suppliers, aiding in its preparation for reactions. Its melting point is often cited around 88-89°C, indicating its solid state at room temperature.

Chemically, ETT functions as an activator in phosphoramidite chemistry, particularly in the synthesis of oligonucleotides. Its ability to protonate phosphoramidite monomers facilitates the phosphite triester linkage formation. Beyond this primary role, its tetrazole ring structure makes it a versatile building block for further chemical synthesis. Researchers exploring tetrazole derivatives for pharmaceutical applications or other novel uses rely on the consistent chemical properties of high-purity ETT supplied by reputable manufacturers.

Safety is a paramount concern when handling any chemical reagent. According to safety data sheets (SDS) and hazard information, ETT can be an irritant. Signal words like 'Danger' may be associated with it, accompanied by hazard statements such as H228 (Flammable solid), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Consequently, appropriate personal protective equipment (PPE) is mandatory when working with ETT. This includes chemical-resistant gloves, safety goggles or a face shield, and laboratory coats. Work should ideally be conducted in a well-ventilated area, such as a fume hood, to minimize inhalation exposure.

Proper storage is also vital to maintain the integrity and safety of ETT. It is often recommended to store it in a cool, dry place, away from incompatible materials such as oxidizing agents. As with many chemical compounds, keeping containers tightly sealed when not in use helps prevent contamination and degradation. When purchasing ETT, it is advisable to consult the supplier's specific recommendations for storage and handling to ensure optimal performance and safety in your laboratory or manufacturing setting.

By adhering to these guidelines for understanding and handling 5-Ethylthio-1H-Tetrazole, researchers and manufacturers can effectively utilize this important chemical intermediate while prioritizing safety.