Ethyl Bromoacetate, identified by its CAS number 105-36-2, is a chemical compound that plays a significant role in numerous industrial processes due to its distinct chemical properties and reactivity. At NINGBO INNO PHARMCHEM CO.,LTD., we delve into the scientific underpinnings of this essential reagent to better understand its applications and value.

Chemically, ethyl bromoacetate is the ethyl ester of bromoacetic acid. It presents as a clear, colorless to light-yellow liquid, with a molecular formula of C4H7BrO2. Its physical characteristics, such as a boiling point of 159°C and a melting point of -38°C, are critical for its handling and processing in various synthetic procedures. The compound possesses a pungent odor and is miscible with most organic solvents like ethanol, ether, and benzene, though it is insoluble in water and can undergo partial decomposition upon contact with it. Its high assay of ≥99.0% ensures purity, which is vital for predictable reaction outcomes.

The reactivity of ethyl bromoacetate is primarily attributed to the presence of the bromine atom and the ester group, making it an effective alkylating agent. This dual functionality allows it to participate in a range of important organic reactions. The Reformatsky reaction, for instance, utilizes ethyl bromoacetate to generate organozinc enolates, which are crucial for the formation of beta-hydroxy esters. These esters are ubiquitous building blocks in the synthesis of pharmaceuticals, natural products, and fine chemicals. The efficiency of the Reformatsky reaction is a testament to the well-understood chemical behavior of ethyl bromoacetate.

Another key reaction involving ethyl bromoacetate is its role in the preparation of Wittig reagents. By reacting with triphenylphosphine, it forms a phosphonium salt, which is a precursor to the phosphorus ylide used in the Wittig reaction. This reaction is fundamental for converting carbonyl compounds into alkenes, a process essential for constructing complex molecular structures found in many organic compounds, including pharmaceuticals and fragrances. The phrase 'Wittig reagent synthesis' frequently appears when discussing the applications of ethyl bromoacetate.

The industrial significance of ethyl bromoacetate extends across multiple sectors. As a pharmaceutical intermediate, it is integral to the synthesis of numerous drug molecules. In the agrochemical industry, it serves as a building block for pesticides and herbicides. Furthermore, its use as a lachrymator and a warning agent in chemical warfare during World War I, though historical, highlights its potent chemical properties. The demand for this chemical is driven by its broad applicability, from fundamental research laboratories to large-scale manufacturing facilities. Understanding the price of ethyl bromoacetate is important for planning chemical synthesis projects.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing ethyl bromoacetate of exceptional purity and quality. Our rigorous testing and quality control ensure that our clients receive a reliable product that meets their specific needs for organic synthesis, pharmaceutical intermediate production, and other industrial applications. By supplying this versatile chemical, we contribute to scientific advancement and industrial progress, solidifying the position of ethyl bromoacetate as a critical component in modern chemistry.