NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality chemical intermediates, and understanding the synthesis of compounds like N-(Diphenylmethylene)glycine methyl ester (CAS 81167-39-7) is fundamental to our operation and our ability to serve clients effectively. This compound, also known as methyl 2-(benzhydrylideneamino)acetate, is a valuable intermediate in organic synthesis, and its efficient production is key.

The most commonly cited synthesis method for N-(Diphenylmethylene)glycine methyl ester involves the reaction between benzophenone imine and glycine methyl ester hydrochloride. This reaction is typically carried out in an anhydrous solvent, such as dichloromethane, under a nitrogen atmosphere to prevent unwanted side reactions and maintain the integrity of the reactants. The process is relatively straightforward, involving simple mixing and stirring over a period of approximately 24 hours.

During the reaction, ammonium chloride is observed to precipitate, indicating the progress of the chemical transformation. Following completion, a work-up procedure involving washing with aqueous solutions (like sodium carbonate and brine) and drying over anhydrous sodium sulfate is performed. The organic layer is then concentrated to yield the crude product. Reports indicate that this synthesis route can achieve near 100% yield, producing a product with approximately 99% purity. This high yield and purity are significant advantages for its industrial application, reducing the need for extensive purification steps.

The successful synthesis of N-(Diphenylmethylene)glycine methyl ester relies on careful control of reaction conditions, including solvent choice, temperature, and reaction time. For businesses looking to purchase this compound, understanding these synthetic details highlights the chemical expertise and quality assurance involved in its production. NINGBO INNO PHARMCHEM CO.,LTD. ensures that its N-(Diphenylmethylene)glycine methyl ester is synthesized and purified to the highest standards, making it a reliable choice for all your synthetic needs.