1,2,4-Butanetriol (CAS 3068-00-6) is an organic compound distinguished by its unique chemical structure and versatile applications. This colorless, odorless, hygroscopic, and flammable viscous liquid possesses three hydrophilic alcoholic hydroxyl groups, classifying it as a polyol. Its structure is similar to glycerol and erythritol, and importantly, it is a chiral molecule, existing as two possible enantiomers.

The preparation of 1,2,4-butanetriol can be achieved through various methods. Traditional chemical synthesis routes include the hydroformylation of glycidol followed by reduction, or the sodium borohydride reduction of esterified malic acid. More recently, significant progress has been made in its biotechnological synthesis, utilizing engineered microorganisms like Escherichia coli. This bio-based approach leverages enzymatic pathways to convert renewable feedstocks into 1,2,4-Butanetriol, offering a more sustainable production method.

The compound's primary applications are found in two key sectors. Firstly, it serves as a crucial chemical precursor for BTTN (Butanetriol Trinitrate), an important military propellant that offers enhanced stability and safety over nitroglycerin. Secondly, in the pharmaceutical industry, 1,2,4-Butanetriol acts as a vital chiral synthon in the synthesis of cholesterol-lowering drugs such as Crestor and Zetia. Its specific stereochemistry is essential for the efficacy of these medications.

The understanding of the uses of 1,2,4-butanetriol is continually expanding, with ongoing research exploring its potential as a monomer for polyesters and as a specialized solvent. NINGBO INNO PHARMCHEM CO.,LTD. is actively involved in supplying high-quality 1,2,4-Butanetriol, supporting the diverse needs of industries that rely on this multifaceted chemical. The consistent demand for this compound highlights its indispensable role in modern chemical manufacturing and technological advancement.