Diphenylphosphoryl Azide (DPPA), identified by its CAS number 26386-88-9, is a chemical compound that has garnered significant attention in the field of organic synthesis due to its unique reactivity and versatility. As a leading supplier of fine chemicals, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality DPPA to researchers and manufacturers worldwide. Understanding its chemical properties is key to unlocking its full potential in various synthetic applications.

DPPA is characterized as a slightly yellow liquid with a distinct boiling point of 157°C at 0.17 mm Hg. Its density is approximately 1.277 g/mL at 25°C, and it possesses a refractive index of n20/D 1.551. Notably, DPPA is insoluble in water, a property that often dictates its use in specific organic solvent systems. Its flash point is above 230°F, indicating a relatively stable nature under normal handling conditions, though proper storage at 2-8°C is recommended to maintain its efficacy. The molecular formula C12H10N3O3P and molecular weight of 275.2 further define its chemical identity.

The primary utility of DPPA lies in its role as an azide transfer reagent. It is extensively used in the Curtius rearrangement for the synthesis of carbamates, offering a safer alternative to isolating potentially explosive carbonyl azides. This feature alone makes DPPA a highly sought-after reagent for fine chemical manufacturing processes where safety and efficiency are paramount. When considering the price of DPPA, its ability to streamline hazardous steps adds significant value to its overall cost-effectiveness.

Beyond carbamate synthesis, DPPA is instrumental in peptide coupling reactions, preventing racemization and ensuring the stereochemical integrity of the resulting peptides. This is crucial for the pharmaceutical industry, where the precise structure of peptide drugs directly impacts their therapeutic efficacy. The compound also finds application in the stereospecific synthesis of azides from alcohols and in various catalytic transformations. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing DPPA that meets rigorous purity standards, enabling reliable performance in these demanding applications. By choosing to buy DPPA from us, you are investing in quality and consistency for your chemical synthesis needs.