Bletilla Striata: A Comprehensive Review of its Chemical Constituents and Pharmacological Activities
Bletilla Striata, a perennial herb belonging to the Orchidaceae family, has a long and distinguished history of use in Traditional Chinese Medicine (TCM). Its tubers, known as Bai Ji, have been employed for centuries to treat a variety of ailments, primarily those involving bleeding and inflammation. Modern scientific inquiry has validated many of these traditional uses and expanded our understanding of this plant's therapeutic potential by meticulously cataloging its chemical constituents and exploring their pharmacological actions.
The phytochemical investigation of Bletilla Striata has revealed an impressive array of chemical compounds. Over 190 monomeric compounds have been identified, falling into several key categories. These include bibenzyls, phenanthrene derivatives, triterpenoids and their saponins, steroids and their saponins, malic acid derivatives, and anthocyanins. Among these, bibenzyls and phenanthrenes are considered particularly characteristic chemotypes of Bletilla Striata. Furthermore, the plant is a significant source of polysaccharides, such as Bletilla Striata Polysaccharide (BSP), which is recognized as a major active component responsible for many of the plant's observed biological activities.
The pharmacological activities of Bletilla Striata are as diverse as its chemical constituents. The plant exhibits significant wound-healing properties, stemming from its ability to promote hemostasis (stopping bleeding) and its role in managing inflammation and tissue repair. Its antimicrobial activity against a range of bacteria, including antibiotic-resistant strains, makes it a promising candidate for new antibacterial agents. Moreover, studies have demonstrated notable anticancer effects, with various compounds showing cytotoxicity against different cancer cell lines and influencing cell cycle progression.
The antioxidative capacity of Bletilla Striata is another area of extensive research. Its extracts and isolated compounds effectively scavenge free radicals, offering protection against cellular damage and contributing to anti-aging effects. The plant also possesses antiviral properties, showing activity against influenza viruses by interfering with viral replication mechanisms. This broad spectrum of pharmacological activities highlights Bletilla Striata's potential as a source for novel therapeutics.
Quality control remains a critical aspect of utilizing Bletilla Striata in pharmaceutical and health products. Factors such as geographical origin, cultivation methods, and specific plant parts used can influence the content and composition of active compounds. Standardization of extracts, often focusing on polysaccharide content or specific marker compounds like militarine, is essential for ensuring consistent efficacy and safety. NINGBO INNO PHARMCHEM CO.,LTD. adheres to rigorous quality control measures to provide reliable Bletilla Striata extract for various applications, supporting research and product development in the fields of medicine, cosmetics, and health supplements.
Perspectives & Insights
Data Seeker X
“This broad spectrum of pharmacological activities highlights Bletilla Striata's potential as a source for novel therapeutics.”
Chem Reader AI
“Quality control remains a critical aspect of utilizing Bletilla Striata in pharmaceutical and health products.”
Agile Vision 2025
“Factors such as geographical origin, cultivation methods, and specific plant parts used can influence the content and composition of active compounds.”