Metabolic research is a dynamic field focused on understanding how organisms process energy and nutrients. Central to these processes is the synthesis of fatty acids, which serve as essential building blocks for cell membranes, energy reserves, and signaling molecules. Fatty acid synthase (FASN) is the key enzyme responsible for de novo fatty acid synthesis, and its dysregulation is implicated in numerous metabolic disorders, including obesity, diabetes, and certain types of cancer. Consequently, molecules that can precisely modulate FASN activity are of great interest to researchers.

Cerulenin, known by its CAS number 17397-89-6, is a potent antibiotic isolated from the fungus *Cephalosporium caerulens*. Its significant contribution to biochemical research lies in its irreversible inhibition of fatty acid and polyketide biosynthesis. The molecular target of Cerulenin is the beta-ketoacyl-ACP synthase (KAS) domain of fatty acid synthase. By binding covalently to a cysteine residue within the active site of KAS, Cerulenin effectively prevents the condensation of acetyl-CoA and malonyl-CoA, thereby halting the elongation of fatty acid chains. This precise mechanism of action allows researchers to study the consequences of impaired fatty acid synthesis in various cellular and organismal models.

The applications of Cerulenin in metabolic research are diverse. Its ability to block fatty acid production makes it a valuable tool for investigating the role of lipogenesis in cellular energy homeostasis, insulin sensitivity, and the development of metabolic diseases. For instance, studies have utilized Cerulenin to explore how inhibiting fatty acid synthesis can influence glucose uptake and metabolism in adipocytes and other cell types. Furthermore, the observed metabolic effects of Cerulenin, which can mimic some effects of leptin on metabolic rate and food intake, suggest its potential utility in understanding complex endocrine and metabolic feedback loops, even though its mechanism differs from leptin's.

Beyond its metabolic roles, Cerulenin's antibiotic properties also make it a subject of interest in microbiology. Its effectiveness against certain bacterial strains underscores the conserved nature of fatty acid synthesis pathways across different life forms. For scientists looking to purchase Cerulenin, its availability as a research chemical facilitates in-depth studies into these multifaceted biological processes. Understanding the chemical synthesis and optimal storage conditions for Cerulenin ensures its efficacy in experimental settings, paving the way for novel discoveries in metabolic health and disease management.