In the realm of advanced pharmaceutical development, understanding the intricate details of key compounds is essential. Dasatinib Monohydrate, a critical player in targeted cancer therapy, is no exception. This article will explore the fundamental Dasatinib Monohydrate chemical properties, delving into its structure, synthesis, and the importance of its quality for pharmaceutical applications.

The chemical identity of Dasatinib Monohydrate is characterized by its IUPAC name, N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide monohydrate, and its molecular formula, C22H26ClN7O2S. Its physical appearance is typically a white powder. These details are crucial for researchers and manufacturers who rely on precise specifications for their work. The compound's molecular weight and other computed descriptors provide a foundation for understanding its behavior in various chemical and biological processes.

The synthesis of Dasatinib Monohydrate is a complex process, with several reported methods aimed at achieving high purity and yield. One common approach involves the nucleophilic coupling of an amino thiazole carboxamide with a dichloropyrimidine derivative, followed by further reactions. The quality of the Dasatinib Monohydrate pharmaceutical intermediate is directly influenced by the efficiency and control of these synthesis steps. Factors like reaction conditions, solvent selection, and purification techniques are critical to obtaining a product suitable for pharmaceutical use.

The therapeutic efficacy of Dasatinib Monohydrate, particularly in leukemia treatment, is heavily dependent on its purity and precise chemical structure. Its role as a tyrosine kinase inhibitor requires a specific molecular configuration to effectively target cancer cells. Therefore, manufacturers who supply this compound must adhere to stringent quality control measures. For those looking to buy Dasatinib Monohydrate online, verifying the supplier's adherence to pharmaceutical standards and the availability of detailed product specifications, including its CAS number, is a critical step.

The ongoing research into optimizing the Dasatinib Monohydrate synthesis method highlights the dynamic nature of pharmaceutical chemistry. Innovations in synthesis not only aim for better yields but also for more sustainable and cost-effective processes. Understanding these advancements is key for anyone involved in the supply chain or application of this vital compound in advancing cancer therapy.

In summary, the detailed chemical blueprint of Dasatinib Monohydrate, from its molecular structure to its synthesis pathways, underscores its significance in modern medicine. Its role as a highly effective therapeutic agent for leukemia patients relies heavily on the meticulous production and quality assurance of this critical pharmaceutical intermediate.