Understanding the detailed chemical profile of a compound is fundamental to its effective utilization in research and industry. Methyl 4-(butyrylamino)-3-methyl-5-nitrobenzoate, identified by CAS number 152628-01-8, is a compound whose structure dictates its reactivity and applications, particularly in the pharmaceutical sector. This article delves into its key chemical properties, shedding light on why it is a sought-after intermediate.

At its core, Methyl 4-(butyrylamino)-3-methyl-5-nitrobenzoate possesses the molecular formula C13H16N2O5, translating to a molecular weight of approximately 280.28 g/mol. This precise composition is the result of a specific arrangement of atoms, including a benzoate ester, an amide linkage, a methyl group, and a nitro group attached to an aromatic ring. The ester group (-COOCH3) can undergo hydrolysis or transesterification, while the amide (-NH-CO-) provides a stable linkage but can be cleaved under harsh conditions. The methyl group (-CH3) influences steric factors and electronic distribution around the ring.

The nitro group (-NO2) is a significant feature. It is a strongly electron-withdrawing group, which impacts the reactivity of the aromatic ring, typically deactivating it towards electrophilic substitution and activating it towards nucleophilic aromatic substitution, especially at positions ortho and para to it. Furthermore, the nitro group can be readily reduced to an amino group (-NH2) using various reducing agents, a common transformation in organic synthesis that opens up pathways to numerous other functionalizations.

The compound's physical appearance is consistently described as a white powder. This solid form is convenient for handling, weighing, and storage in laboratory and industrial settings. Its solubility characteristics are also important; it is generally soluble in common organic solvents, which is essential for its use in solution-phase chemical reactions. While specific solubility data can vary, its polar functional groups suggest some solubility in moderately polar organic solvents.

The significance of these properties becomes clear when considering its primary application as a Sartan intermediate. The synthesis of Sartans involves intricate organic chemistry, where the nitro group might be reduced to an amine, which then participates in further reactions, or the ester might be modified. The presence of these specific functional groups in Methyl 4-(butyrylamino)-3-methyl-5-nitrobenzoate makes it an ideal starting point for constructing the complex molecular architectures of Sartan drugs. NINGBO INNO PHARMCHEM CO.,LTD plays a crucial role in providing this essential compound with a well-defined chemical profile.

In summary, the chemical properties of Methyl 4-(butyrylamino)-3-methyl-5-nitrobenzoate – its molecular structure, weight, functional groups, and physical form – collectively define its utility. As a reliable intermediate, it empowers advancements in pharmaceutical synthesis, enabling the creation of critical medications like Sartans, and supports broader chemical research efforts.