Understanding the chemical profile of pharmaceutical intermediates is fundamental for their effective use in research and manufacturing. Riociguat Intermediate, also identified as Riociguat Impurity 21 and bearing the CAS number 256376-65-5, is a compound of significant interest in the pharmaceutical sector. Its specific chemical and physical properties dictate its utility in various applications, from intricate synthesis pathways to precise analytical procedures.

The chemical formula for Riociguat Intermediate is C14H9FN4, with a molecular weight of approximately 252.25 g/mol. This structure contains key functional groups that make it suitable as a precursor or a reference standard. The compound typically appears as a yellow to dark yellow powder, indicating its physical form and color, which are important visual identifiers for quality control. Its melting point is recorded in the range of 80-82°C, providing a specific characteristic for identification and purity assessment.

The specified usage of Riociguat Intermediate highlights its distinct roles within the pharmaceutical industry. Primarily, it is utilized as a reagent for PRO analysis and for synthesis purposes, positioning it as a critical component in the production of Riociguat. Riociguat itself is a first-in-class stimulator of soluble guanylate cyclase (sGC), used in treating pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). The availability of a high-purity intermediate is essential for the efficient and safe synthesis of this complex API.

Furthermore, the compound serves as an Analytical Reagent, which means it is used in laboratories for testing and analysis. In pharmaceutical quality control, analytical reagents are used to develop methods for identifying and quantifying substances, including impurities. Riociguat Intermediate, in this context, acts as a reference standard, allowing for the accurate assessment of Riociguat's purity and the detection of any related impurities. This application is crucial for meeting stringent regulatory requirements and ensuring the safety and efficacy of the final drug product.

The classification of Riociguat Intermediate as a 'Chemical Medicine' and its application in 'Scientific Research' and 'Health' sectors further emphasize its importance. It is a versatile compound employed in various stages of drug development, from early research into new therapeutic compounds to the detailed quality assurance of manufactured pharmaceuticals. Manufacturers like Nanjing Xinbell Pharmaceutical Technology Co., Ltd. ensure that such intermediates are produced with the necessary specifications and documentation to support these diverse and demanding applications.

In essence, the detailed chemical and physical properties of Riociguat Intermediate make it an indispensable tool for pharmaceutical professionals. Understanding its formula, molecular weight, melting point, and intended uses allows researchers and manufacturers to harness its full potential in advancing drug development and ensuring product quality.