Fmoc-D-Tyr(4-Et)-OH is a specialized amino acid derivative that plays a significant role in modern organic and peptide synthesis. Understanding its chemical properties and synthesis is crucial for researchers aiming to utilize it effectively in their projects. This article provides an overview of the chemical characteristics of Fmoc-D-Tyr(4-Et)-OH, commonly identified by its CAS number 162502-65-0, and touches upon its preparation.

Chemically, Fmoc-D-Tyr(4-Et)-OH is a protected form of D-tyrosine, where the amino group is protected by the Fmoc moiety, and the hydroxyl group of the tyrosine side chain is modified with an ethyl ether. The molecular formula is C26H25NO5, with a molecular weight of approximately 431.48 g/mol. Its appearance is typically described as a white to off-white solid. The Fmoc group is known for its base-lability, allowing for its selective removal under mild basic conditions (e.g., using piperidine), which is a cornerstone of Fmoc-based peptide synthesis. The ethoxy modification on the tyrosine side chain (4-ethoxyphenyl) can influence the compound's solubility and reactivity compared to unmodified tyrosine derivatives. Researchers often refer to it using its various synonyms, such as Fmoc-O-ethyl-D-tyrosine, when discussing its Fmoc-D-Tyr(4-Et)-OH applications.

The synthesis of Fmoc-D-Tyr(4-Et)-OH typically involves the reaction of D-tyrosine with Fmoc-Cl or Fmoc-OSu to introduce the Fmoc protecting group onto the alpha-amino group. Subsequently, the hydroxyl group of the tyrosine side chain is etherified, often through an alkylation reaction using an ethylating agent, to form the 4-ethoxy derivative. The precise sequence and conditions of these reactions are critical to achieving high yields and purity. The availability of high-quality starting materials and optimized reaction protocols are key factors in the cost-effective production of this compound. Therefore, when considering the Fmoc-D-Tyr(4-Et)-OH price, it's important to consider the complexity of its synthesis.

For researchers intending to buy Fmoc-D-Tyr(4-Et)-OH, understanding its chemical properties also extends to storage and handling. It is generally recommended to store this compound in a cool, dry place, often under refrigeration (2-8°C), to maintain its stability and prevent degradation. Proper handling procedures should be followed to avoid contamination and ensure the integrity of the material. The selection of reliable Fmoc-D-Tyr(4-Et)-OH suppliers who adhere to strict quality control measures is paramount.

The utility of Fmoc-D-Tyr(4-Et)-OH, particularly the Fmoc-O-ethyl-D-tyrosine usage, lies in its ability to introduce a chemically modified tyrosine residue into peptide chains. This modification can serve various purposes, including enhancing the stability of the peptide, probing interactions with biological targets, or serving as a research tool in chemical biology. NINGBO INNO PHARMCHEM CO.,LTD. focuses on providing this intermediate with guaranteed purity for all your advanced synthesis needs.

In summary, Fmoc-D-Tyr(4-Et)-OH is a product of sophisticated organic synthesis, possessing distinct chemical properties that make it invaluable for advanced research. A thorough understanding of its structure, synthesis, and handling ensures its effective application in driving scientific discovery forward.