Amino acid derivatives are the foundational elements of modern peptide chemistry, and understanding their structure and protective groups is key to successful synthesis. NINGBO INNO PHARMCHEM CO.,LTD. specializes in providing these intricate molecules, including Boc-D-His(Tos)-OH, a compound that exemplifies sophisticated amino acid protection strategies.

Boc-D-His(Tos)-OH (CAS 69541-68-0) is a protected form of D-histidine. Its name reveals its crucial chemical features: 'Boc' refers to the tert-butyloxycarbonyl group, a widely used acid-labile protecting group for amines. This group is attached to the alpha-amino nitrogen of the D-histidine. The 'D' signifies the D-enantiomer, which is often employed to impart enhanced stability or altered pharmacological properties to peptides. The 'Tos' or tosyl group, chemically known as p-toluenesulfonyl, is attached to the imidazole ring of the histidine side chain. This imidazole ring is inherently nucleophilic and can undergo side reactions during peptide synthesis if not properly protected.

The dual protection of Boc-D-His(Tos)-OH by NINGBO INNO PHARMCHEM CO.,LTD. is designed for robust performance in solid-phase peptide synthesis (SPPS). The Boc group is removed using mild acidic conditions (e.g., trifluoroacetic acid, TFA), freeing the alpha-amino group for coupling with the next activated amino acid. Crucially, the tosyl group on the imidazole is stable under these Boc-deprotection conditions and also during peptide cleavage from the resin. It is typically removed in later stages of synthesis, often using stronger acidic conditions or specific reagents, ensuring that the histidine side chain remains unmodified throughout the elongation process. Researchers often seek to buy Boc-D-His(Tos)-OH specifically for its reliable and orthogonal protection scheme.

The chemical formula for this compound is C18H23N3O6S, with a molecular weight of approximately 409.5 g/mol. Its structure makes it an ideal building block for incorporating histidine residues into peptides, especially where the imidazole nitrogen needs to be unreactive during specific synthesis steps. NINGBO INNO PHARMCHEM CO.,LTD. ensures that its supply of this Boc-D-Histidine tosyl derivative is of the highest purity, critical for maintaining the integrity of the peptide synthesis reagents and the final peptide product.

Understanding the chemistry behind Boc-D-His(Tos)-OH also highlights the importance of selecting the correct CAS 69541-68-0 supplier. A reputable supplier like NINGBO INNO PHARMCHEM CO.,LTD. guarantees that the product's structure and purity are as specified, enabling researchers and manufacturers to confidently use it in their complex synthetic pathways, whether for standard peptide production or for creating highly specialized custom peptide synthesis building blocks.

In essence, Boc-D-His(Tos)-OH represents a triumph of chemical protection strategy, enabling sophisticated peptide synthesis. NINGBO INNO PHARMCHEM CO.,LTD.'s role in providing this crucial amino acid derivative supports the ongoing advancements in chemical biology and pharmaceutical sciences.