At NINGBO INNO PHARMCHEM CO.,LTD., we delve into the intricate chemistry that drives pharmaceutical innovation. Today, we focus on Pagoclone (CAS 133737-32-3), a compound whose pharmacological action is deeply rooted in its interaction with GABAA receptors.

Pagoclone belongs to the cyclopyrrolone class and is characterized by its molecular formula C23H22ClN3O2. Its chemical structure facilitates its role as a partial agonist at specific GABAA receptors. The GABAA receptor is the principal inhibitory neurotransmitter receptor in the mammalian brain, and its modulation is a key target for many therapeutic agents, particularly for anxiety and related disorders. Pagoclone's ability to selectively interact with certain subunits of the GABAA receptor complex is what underlies its therapeutic potential.

As a partial agonist, Pagoclone binds to the benzodiazepine site on the GABAA receptor. This binding mechanism means it can activate the receptor, but to a lesser extent than a full agonist. This characteristic is thought to contribute to its anxiolytic effects with a potentially reduced risk of certain side effects, such as excessive sedation or cognitive impairment, compared to full agonists. Understanding these specific interactions is crucial for researchers looking to buy Pagoclone for advanced studies.

The nuanced action of Pagoclone on GABAA receptors has also led to its exploration in other neurological contexts, including its potential to improve speech fluency in stuttering. This multifaceted activity highlights the complexity of neurochemical signaling and the potential for single compounds to influence diverse physiological processes. NINGBO INNO PHARMCHEM CO.,LTD. plays a vital role by providing this chemical as a reliable pharmaceutical intermediate to support such research.

For scientific institutions and pharmaceutical companies, accessing high-purity Pagoclone is essential for accurate research. NINGBO INNO PHARMCHEM CO.,LTD. serves as a premier Pagoclone supplier in China, ensuring that the scientific community has the resources needed to investigate compounds like Pagoclone. We are dedicated to facilitating advancements in neuroscience and pharmacology by providing the chemical building blocks for discovery.