NINGBO INNO PHARMCHEM CO.,LTD. supplies a wide array of pharmaceutical-grade Hypromellose (HPMC) products, each tailored to specific applications within drug formulation. Selecting the correct HPMC grade is crucial for achieving desired product performance, from tablet binding and film coating to sustained drug release and ophthalmic solutions. This guide aims to assist formulators in making informed decisions.

The primary differentiating factors among HPMC grades are their viscosity and substitution patterns (specifically, the degree of methoxy and hydroxypropoxy substitution). Viscosity is typically measured in MPa.s (or cps) for a standard 2% aqueous solution at 20-25°C. Lower viscosity grades are generally preferred for applications requiring good flow and film formation, such as tablet coatings and eye drops. For example, lower viscosity hypromellose for eye drops ensures a comfortable application and good spreading on the ocular surface.

Higher viscosity grades of HPMC are often utilized for their thickening and binding capabilities in tablet formulations. Our pharmaceutical grade HPMC for tablets comes in a range of viscosities that allow formulators to achieve the desired tablet hardness and disintegration profile. When used as a binder, higher viscosity grades create stronger bonds between powder particles, leading to tablets that can withstand processing and transport.

The substitution type also plays a significant role, influencing properties like solubility, gelation temperature, and surface activity. For instance, the 2208 substitution type, commonly found in sustained release HPMC, is known for its excellent film-forming and gelation properties, which are essential for creating drug release matrices. Understanding these types is key to developing effective sustained release HPMC formulations.

When it comes to tablet film coating, a balance is needed. Our HPMC for film coating needs to form a uniform, cohesive film that is not too brittle or too sticky. Grades with medium to high viscosity are often preferred as they provide adequate film strength and coverage. Similarly, for empty capsules, the hydroxypropyl methyl cellulose for capsules must form a strong, flexible film that can be reliably manufactured into capsules.

For specialized applications like controlled release formulations, selecting the appropriate HPMC is paramount. The degree of substitution and molecular weight (which correlates with viscosity) directly impact the rate at which the polymer hydrates, swells, and erodes, thereby controlling drug release. Manufacturers looking to buy HPMC for these purposes should consult with their supplier to identify the grade that best matches their desired release profile.

NINGBO INNO PHARMCHEM CO.,LTD. offers a comprehensive portfolio of pharmaceutical grade HPMC, including various substitution types and viscosity grades. Our technical team is available to provide expert advice, helping you navigate these choices to find the optimal HPMC solution for your specific pharmaceutical application, whether it’s for tablets, capsules, eye drops, or other innovative drug delivery systems.