2-(2-Chloroethoxy)ethanol, identified by its CAS number 628-89-7, is a chemical compound that holds significant importance in both the pharmaceutical industry and broader organic synthesis. Understanding its distinct chemical and physical properties is key to appreciating its utility and safe handling in various industrial and research settings.

Key Chemical and Physical Characteristics

As a clear liquid, 2-(2-Chloroethoxy)ethanol typically presents as colorless to a very light yellow hue. Its molecular formula is C4H9ClO2, with a molecular weight of 124.57 g/mol. The compound exhibits a boiling point range of 79-81°C when measured at 5 mm Hg pressure, distinguishing it from many other common solvents. Its density is reported as 1.18 g/mL, and it possesses a flash point of 195°F. These physical attributes are vital for process engineers and chemists when designing reactions, determining storage conditions, and ensuring safe operational parameters. The compound's solubility in water also contributes to its versatility in various chemical processes.

Diverse Applications in Synthesis

The primary value of 2-(2-Chloroethoxy)ethanol lies in its role as a chemical intermediate. Its structure makes it an ideal starting material for synthesizing more complex molecules. In the pharmaceutical sector, it is a crucial component in the production of several important APIs. Most notably, it is used in the synthesis of Quetiapine and Quetiapine fumarate, which are essential antipsychotic medications. Its incorporation into these drug molecules is a well-established process, highlighting its significance in modern medicine. Additionally, it finds application in the synthesis of other pharmaceuticals such as Hydroxyzine HCl and Cetirizine HCl, further expanding its impact on healthcare.

Beyond pharmaceutical applications, 2-(2-Chloroethoxy)ethanol is also valuable in general organic synthesis. It can be employed in the creation of various organic chemical raw materials and fine chemicals. Researchers often utilize it to explore novel synthetic pathways or to produce specialty chemicals with specific properties. The consistent availability of this compound from reliable suppliers like NINGBO INNO PHARMCHEM CO.,LTD. ensures that these research and manufacturing efforts can proceed without interruption.

Safety and Handling Guidelines

Due to its chemical nature, 2-(2-Chloroethoxy)ethanol is classified with hazard symbol Xi, indicating it can be an irritant. Proper safety protocols are therefore essential during its handling. This includes wearing appropriate personal protective equipment (PPE) such as gloves, eye protection, and protective clothing. In case of accidental contact with skin or eyes, immediate flushing with plenty of water is recommended. While it is noted as non-flammable, good industrial hygiene practices should always be followed.

Conclusion

2-(2-Chloroethoxy)ethanol stands out as a chemical of considerable importance due to its well-defined properties and its essential function as an intermediate, particularly in the pharmaceutical industry. Its contribution to the synthesis of critical medications underscores the need for rigorous quality control and reliable sourcing. Whether for large-scale pharmaceutical production or intricate organic synthesis research, understanding the profile of 2-(2-Chloroethoxy)ethanol is key to its effective and safe utilization.