Exploring Organic Synthesis Applications of (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol
While (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol (CAS 1006376-60-8) is widely recognized as a crucial intermediate in the synthesis of the cardiovascular drug Ticagrelor, its utility as an organic synthesis building block extends further into the realms of chemical research and development. Its molecular architecture, featuring a reactive chlorine atom, a chiral alcohol group, and a difluorinated phenyl ring, provides chemists with a versatile platform for constructing a variety of complex organic molecules.
The presence of the difluorophenyl moiety, for instance, can impart enhanced metabolic stability and altered lipophilicity to molecules. This makes (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol an attractive starting material for researchers exploring new chemical entities in areas such as agrochemicals, material science, and other specialized pharmaceutical applications. The ability to selectively manipulate the chlorine atom or the alcohol group allows for a range of transformations, leading to diverse derivative compounds. Thus, companies looking to buy (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol are not just investing in a drug precursor but in a tool for broader chemical innovation.
The demand for high-quality intermediates like this underscores the importance of a robust chemical supply chain. Sourcing from reliable pharmaceutical intermediate suppliers ensures that researchers have access to materials that meet stringent purity and structural requirements. The precise synthesis of (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol, particularly maintaining its specific (1S) chirality, is key to its successful application in diverse synthetic strategies. As research continues to uncover new applications for these specialized fluorinated compounds, the role of such versatile building blocks in driving scientific progress becomes increasingly evident, cementing their value within the chemical industry.
Perspectives & Insights
Chem Catalyst Pro
“The presence of the difluorophenyl moiety, for instance, can impart enhanced metabolic stability and altered lipophilicity to molecules.”
Agile Thinker 7
“This makes (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol an attractive starting material for researchers exploring new chemical entities in areas such as agrochemicals, material science, and other specialized pharmaceutical applications.”
Logic Spark 24
“The ability to selectively manipulate the chlorine atom or the alcohol group allows for a range of transformations, leading to diverse derivative compounds.”