Exploring the Synthesis and Chemical Properties of 2-Amino-5-Fluoropyridine
Understanding the synthesis and chemical properties of key intermediates is fundamental to progress in organic chemistry and its applied fields. 2-Amino-5-Fluoropyridine, a compound identified by CAS number 21717-96-4, is one such intermediate, valued for its role in pharmaceuticals and agrochemicals. NINGBO INNO PHARMCHEM CO.,LTD. is a leading producer of this compound and is committed to sharing insights into its creation and behavior.
The synthesis of 2-Amino-5-Fluoropyridine typically involves a multi-step process, often starting from more readily available pyridine derivatives. A common and effective route begins with 2-aminopyridine. This starting material undergoes a series of chemical transformations including nitrification, acetylation of the amino group, reduction of the nitro group, diazotization, and crucially, the Schiemann reaction to introduce the fluorine atom at the desired position. Subsequent hydrolysis of the acetyl group yields the final product. This method is favored for its efficiency and ability to produce high yields of pure 2-Amino-5-Fluoropyridine, a critical factor for its downstream applications. For those looking to purchase 2-Amino-5-Fluoropyridine, NINGBO INNO PHARMCHEM CO.,LTD. ensures adherence to these rigorous synthesis standards, offering competitive pricing.
The chemical properties of 2-Amino-5-Fluoropyridine are largely dictated by its molecular structure. The presence of the electron-withdrawing fluorine atom at the 5-position influences the electron density distribution within the pyridine ring, affecting its reactivity in electrophilic and nucleophilic substitution reactions. Simultaneously, the amino group at the 2-position acts as an activating group and can participate in various reactions, such as acylation, alkylation, and Schiff base formation. This dual functionality makes it an exceptionally versatile building block for constructing complex organic molecules. NINGBO INNO PHARMCHEM CO.,LTD. provides this intermediate, allowing researchers to leverage these properties.
The compound typically presents as a white to orange powder with a melting point in the range of 93-97 °C. Its solubility in common organic solvents like methanol further enhances its utility in various reaction conditions. The molecular formula C5H5FN2 and a molecular weight of approximately 112.11 g/mol are key identifiers for this compound. When considering the purchase of 2-Amino-5-Fluoropyridine, understanding these basic properties is essential for experimental design. NINGBO INNO PHARMCHEM CO.,LTD. ensures that the product specifications meet these typical characteristics and often exceed them in terms of purity.
Furthermore, 2-Amino-5-Fluoropyridine serves as a precursor in the synthesis of various biologically active compounds. Its role in creating pharmaceuticals and agrochemicals relies heavily on its ability to undergo targeted modifications and couplings. The consistent quality and availability of this intermediate are therefore crucial for the success of research and development projects in these industries. NINGBO INNO PHARMCHEM CO.,LTD. is a leading manufacturer and supplier, dedicated to ensuring a reliable supply chain for 2-Amino-5-Fluoropyridine at competitive market prices.
In conclusion, a thorough understanding of the synthesis and chemical properties of 2-Amino-5-Fluoropyridine (CAS 21717-96-4) highlights its significance as a versatile intermediate. NINGBO INNO PHARMCHEM CO.,LTD. is a trusted source for this compound, committed to supporting scientific advancement through the provision of high-quality chemicals. We encourage chemists and manufacturers to explore the potential of 2-Amino-5-Fluoropyridine for their synthesis needs.
Perspectives & Insights
Silicon Analyst 88
“Simultaneously, the amino group at the 2-position acts as an activating group and can participate in various reactions, such as acylation, alkylation, and Schiff base formation.”
Quantum Seeker Pro
“This dual functionality makes it an exceptionally versatile building block for constructing complex organic molecules.”
Bio Reader 7
“The compound typically presents as a white to orange powder with a melting point in the range of 93-97 °C.”