Chemical coupling reactions have revolutionized modern organic synthesis, enabling the efficient construction of complex molecules with precise control. Among the diverse reagents available, organoboron compounds, particularly boronic acids, are indispensable tools. This article delves into the utility of 4-Carboxy-3-fluorophenylboronic acid (CAS 120153-08-4), focusing on its mastery in chemical coupling reactions and its role as a high-value building block for various applications, including pharmaceutical intermediates. NINGBO INNO PHARMCHEM CO.,LTD., a prominent manufacturer in China, is a key supplier of this essential chemical.

4-Carboxy-3-fluorophenylboronic acid is a versatile compound with the chemical formula C7H6BFO4 and a molecular weight of 183.93 g/mol. It is typically supplied as a white powder and exhibits solubility in water, facilitating its use in a range of reaction conditions. The molecule's structure is key to its reactivity: a phenyl ring bearing a carboxylic acid group, a fluorine substituent, and the crucial boronic acid moiety. This specific arrangement makes it an ideal participant in palladium-catalyzed cross-coupling reactions, most notably the Suzuki-Miyaura coupling.

The Suzuki-Miyaura coupling reaction is celebrated for its robustness, functional group tolerance, and the mild conditions under which it can be performed. 4-Carboxy-3-fluorophenylboronic acid is a preferred substrate in this reaction because its boronic acid group readily undergoes transmetallation with palladium catalysts, forming a transient organopalladium species that then couples with an organohalide or pseudohalide. This process is fundamental for creating new carbon-carbon bonds, allowing for the synthesis of biaryl compounds and other complex structures vital for pharmaceuticals, agrochemicals, and materials science. For chemists looking to buy this compound, its consistent performance in these reactions, especially when sourced from a reliable manufacturer, is paramount.

The presence of the fluorine atom on the phenyl ring can subtly influence the electronic properties of the molecule, potentially enhancing the reactivity or selectivity in certain coupling reactions. Furthermore, fluorine substitution is often employed in drug design to improve pharmacokinetic profiles, making 4-Carboxy-3-fluorophenylboronic acid a valuable asset in the development of new therapeutics. High purity (≥98.0%) is essential for ensuring efficient coupling and minimizing side reactions. Sourcing this critical reagent from established manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. in China guarantees access to a dependable supply of a high-quality product, supporting seamless research and production workflows. Mastering chemical coupling with such advanced building blocks is a key strategy for innovation in chemistry.