NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing researchers with high-quality chemical building blocks. Among these, Boc-Isonipecotic acid, also known as N-BOC-piperidine-4-carboxylic acid (CAS: 84358-13-4), stands out as an exceptionally useful compound in the realm of organic chemistry. This article serves as a comprehensive guide to understanding its properties, synthesis, and diverse applications.

Boc-Isonipecotic acid is characterized by its white crystalline powder form and a molecular formula of C₁₁H₁₉NO₄. Its structure features a piperidine ring, a crucial heterocyclic motif found in many biologically active compounds. The presence of the tert-butoxycarbonyl (Boc) protecting group on the nitrogen atom is key to its utility. This group is stable under a range of reaction conditions, particularly basic ones, but can be easily removed with acid, allowing for selective functionalization at other parts of the molecule, most notably the carboxylic acid group at the 4-position.

The N-BOC-piperidine-4-carboxylic acid synthesis typically involves reacting isonipecotic acid with di-tert-butyl dicarbonate (Boc anhydride) in the presence of a suitable base. This reaction is generally efficient and can be scaled up, making it accessible for both laboratory research and industrial production. The purity of the final product is crucial, and manufacturers often employ rigorous purification techniques, such as recrystallization or chromatography, to ensure high-grade material is available for demanding applications.

As a versatile chemical synthesis building block, Boc-Isonipecotic acid finds extensive use in the creation of more complex molecules. It is frequently employed in amide couplings, esterifications, and as a precursor for various heterocycles. Its application as a pharmaceutical intermediate is particularly noteworthy, contributing to the development of drugs targeting neurological disorders, pain management, and inflammatory conditions. The ability to readily incorporate this piperidine scaffold into larger molecules makes it a valuable asset in drug discovery and development.

Researchers looking to purchase N-BOC-piperidine-4-carboxylic acid will find it listed under various synonyms, including 1-Boc-4-piperidinecarboxylic acid. Its CAS number, 84358-13-4, is the universally recognized identifier. The compound's solubility characteristics, being insoluble in water but soluble in many organic solvents, also contribute to its ease of use in various synthetic procedures. Understanding these properties is key to successfully integrating Boc-Isonipecotic acid into complex synthetic routes.

In summary, Boc-Isonipecotic acid represents a fundamental tool for chemists engaged in sophisticated synthesis projects. Its reliable synthesis, coupled with its inherent chemical versatility and importance as a piperidine derivative in drug discovery, solidifies its position as an indispensable intermediate in modern organic and medicinal chemistry.