N-Acetylsulfanilyl Chloride, identified by CAS number 121-60-8, is a chemical compound characterized by its distinct molecular structure and reactivity, making it a crucial intermediate in various industrial applications, particularly in pharmaceuticals, dyes, and agrochemicals. A thorough understanding of its chemical properties and synthesis pathways is essential for chemists and manufacturers who utilize this compound. NINGBO INNO PHARMCHEM CO.,LTD. provides insights into these critical aspects.

Chemical Structure and Properties: The molecular formula of N-Acetylsulfanilyl Chloride is C8H8ClNO3S, with a molecular weight of approximately 233.67 g/mol. It typically appears as a white to off-white crystalline powder. Key physical properties include a melting point range of 142-145°C (with decomposition) and a high boiling point. Its solubility is noted in organic solvents like acetone and DMF, but it reacts with water and alcohols, highlighting its sensitivity and the need for anhydrous handling. The presence of the sulfonyl chloride (-SO2Cl) group is central to its reactivity, allowing it to readily undergo nucleophilic substitution reactions, especially with amines to form sulfonamide bonds.

Synthesis Pathways: The production of N-Acetylsulfanilyl Chloride typically involves the chlorosulfonation of acetanilide. A common method starts with acetanilide, which is treated with chlorosulfonic acid. This reaction is often carried out at controlled temperatures, for instance, initially at 20°C, then heated to 55°C for 1.5 hours. Following this, the reaction mixture is cooled and carefully added to ice-cold water, causing the N-Acetylsulfanilyl Chloride to precipitate. The solid is then filtered and washed to remove residual acids. Alternative routes may involve thionyl chloride or other reagents to achieve the desired sulfonyl chloride functionality. The purity of the final product, often exceeding 98%, is a testament to the precision of these synthetic methods, making it a sought-after pharmaceutical intermediate.

Reactivity and Applications: The reactive sulfonyl chloride group makes N-Acetylsulfanilyl Chloride a potent electrophile. Its primary utility lies in its ability to react with amines to form stable sulfonamide linkages. This reaction is fundamental to the synthesis of sulfa drugs, a class of antibiotics vital for treating bacterial infections. It's also used in preparing antidiabetic agents, diuretics, and other therapeutic compounds. In the dye industry, it serves as an intermediate for synthesizing various colorants, while in agrochemicals, it's used in the production of herbicides. To effectively buy N-Acetylsulfanilyl Chloride, understanding these chemical interactions is key.

Handling and Storage: Due to its moisture sensitivity, N-Acetylsulfanilyl Chloride must be stored in tightly sealed containers in a cool, dry place, preferably under refrigeration (2-8°C). Exposure to moisture can lead to hydrolysis, reducing its efficacy. Proper safety precautions, including the use of PPE and adequate ventilation, are essential during handling due to its corrosive nature. NINGBO INNO PHARMCHEM CO.,LTD. emphasizes these aspects to ensure the safe and effective use of their products.

In essence, N-Acetylsulfanilyl Chloride (CAS 121-60-8) is a chemically versatile compound whose specific properties and well-defined synthesis pathways make it an indispensable intermediate. Its role in critical industries underscores the importance of sourcing high-quality material from reliable suppliers like NINGBO INNO PHARMCHEM CO.,LTD.