NINGBO INNO PHARMCHEM CO.,LTD. explores the foundational chemical properties and common synthesis routes for Boc-L-4-Methylphenylalanine, a compound of significant importance in organic chemistry and particularly in peptide synthesis. Known by its CAS number 80102-26-7, this protected amino acid derivative provides chemists with a versatile building block, enabling the construction of complex molecular architectures.

The chemical identity of Boc-L-4-Methylphenylalanine is defined by its phenylalanine backbone, featuring a methyl group at the para position of the phenyl ring and a tert-butoxycarbonyl (Boc) group attached to the alpha-amino nitrogen. This Boc protection is a cornerstone of its utility in solid-phase peptide synthesis (SPPS) and solution-phase peptide coupling. The Boc group is stable under various reaction conditions but can be selectively cleaved using mild acidic conditions, such as trifluoroacetic acid (TFA), without damaging the growing peptide chain. This characteristic makes it highly valuable for controlled and sequential amino acid additions.

Physically, Boc-L-4-Methylphenylalanine typically presents as a white to off-white solid or powder. Its melting point range, often cited between 84-88 °C, is a key indicator of its purity. The compound exhibits slight solubility in water but is generally more soluble in organic solvents commonly used in synthesis, such as methanol, ethanol, or dichloromethane. Its optical activity, often specified as [α]20/D +16° (c=1 in methanol), confirms its stereochemical integrity, which is critical for its function as a chiral building block.

The synthesis of Boc-L-4-Methylphenylalanine generally involves the protection of the amino group of 4-methyl-L-phenylalanine with the Boc anhydride (di-tert-butyl dicarbonate) in the presence of a base. The starting material, 4-methyl-L-phenylalanine, can itself be synthesized through various routes, often involving the functionalization of phenylalanine or related precursors. Researchers often seek to buy Boc-L-4-Methylphenylalanine that has been synthesized efficiently and purified to high standards to ensure reproducibility in their downstream applications, such as in the creation of novel peptides or as a pharmaceutical intermediate.

Understanding these chemical properties and synthesis pathways is essential for chemists looking to leverage this compound effectively. NINGBO INNO PHARMCHEM CO.,LTD. is committed to supplying researchers with this vital chiral amino acid Boc-L-4-methylphenylalanine, supporting advancements in fields ranging from drug discovery to material science. Its role as a key component in various synthetic strategies solidifies its importance in the chemical landscape.