NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing comprehensive information about the chemical products we supply. Today, we focus on Boc-L-glutamic acid 1-tert-butyl ester (CAS 24277-39-2), a compound vital for various chemical applications. Understanding its chemical properties and synthesis pathways is key to its effective utilization in research and production.

Boc-L-glutamic acid 1-tert-butyl ester is characterized by its molecular formula C14H25NO6 and a molecular weight of approximately 303.35 g/mol. As a white powder, it exhibits good solubility in many common organic solvents, which is advantageous for its use in solution-phase reactions. The presence of the tert-butoxycarbonyl (Boc) group on the alpha-amino nitrogen and the tert-butyl ester on the gamma-carboxylic acid are crucial features. The Boc group is acid-labile, allowing for its removal under relatively mild acidic conditions (e.g., using trifluoroacetic acid), a common step in peptide synthesis to expose the amino group for subsequent coupling reactions. The tert-butyl ester serves as a protecting group for the carboxylic acid, which can be cleaved by acidic conditions or other specific deprotection methods, offering orthogonal protection strategies when combined with other protecting groups.

The synthesis of Boc-L-glutamic acid 1-tert-butyl ester typically begins with L-glutamic acid. The process involves selective protection of the amino group with the Boc moiety and esterification of one of the carboxylic acid groups with tert-butanol. Common methods include reacting L-glutamic acid with di-tert-butyl dicarbonate (Boc anhydride) in the presence of a base to introduce the Boc group, followed by esterification. Alternatively, selective esterification can be performed first, followed by Boc protection. The precise order and conditions of these reactions are optimized to ensure high regioselectivity and yield, minimizing the formation of undesired isomers or byproducts. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. employ optimized synthetic routes to produce this compound with the high purity demanded by the industry.

The careful selection of reaction conditions, reagents, and purification techniques is paramount in obtaining the 99% purity that our clients rely on. NINGBO INNO PHARMCHEM CO.,LTD. invests in robust analytical capabilities to verify the quality of each batch, ensuring that our Boc-L-glutamic acid 1-tert-butyl ester meets the stringent requirements for peptide synthesis, pharmaceutical intermediates, and other fine chemical applications. Our expertise in synthesis and quality control makes us a reliable source for this important chemical.