The synthesis of complex pharmaceutical molecules is a testament to the power of modern organic chemistry. Idelalisib, a targeted inhibitor of PI3Kδ, is a prime example of such a molecule, and its production relies heavily on specific, high-quality chemical intermediates. Among these, Boc-L-2-aminobutyric acid (CAS 34306-42-8) plays a truly pivotal role, serving as a critical chiral building block in its intricate synthesis.

The journey from basic raw materials to a finished drug like Idelalisib involves numerous carefully orchestrated chemical reactions. Boc-L-2-aminobutyric acid, with its protected amine group and specific stereochemistry, is introduced at a key stage. Its structure, often referred to as (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid or N-tert-butoxycarbonyl-L-ethylglycine, is precisely what is needed to construct a significant portion of the Idelalisib molecule. The tert-butoxycarbonyl (Boc) group is a common protecting group in organic synthesis, easily removed later in the synthetic sequence without disturbing other parts of the molecule.

The synthesis pathways for Idelalisib often involve coupling reactions where Boc-L-2-aminobutyric acid is linked with other molecular fragments. The chirality of the L-form of 2-aminobutyric acid is crucial for the biological activity of Idelalisib. Using an intermediate with the correct stereochemistry from the outset simplifies the overall synthesis and avoids costly and complex chiral resolution steps later on. This is why sourcing Boc-L-2-aminobutyric acid with a guaranteed high enantiomeric purity is essential for manufacturers.

Patents and scientific literature detailing the preparation of Idelalisib frequently cite Boc-L-2-aminobutyric acid as a key starting material or intermediate. For instance, preparation methods often describe its reaction with other intermediates, such as fluorinated benzoyl chlorides or phenylbenzamides, through amidation or condensation reactions. The efficiency and yield of these early steps are directly influenced by the purity and reactivity of the Boc-L-2-aminobutyric acid used. Therefore, manufacturers in China and globally focus on producing this compound to stringent specifications.

When considering the buy/purchase of Boc-L-2-aminobutyric acid, its physical and chemical properties, such as its melting point range of 61-68°C and its white to off-white powder appearance, are indicators of its quality. However, the most critical specification remains its high assay (u226598.5%) and correct chirality.

In summary, the synthesis of Idelalisib is a complex process where the role of Boc-L-2-aminobutyric acid cannot be overstated. It is not merely a reagent but a foundational piece of the molecular puzzle, enabling the creation of a vital therapeutic agent. Its reliable supply and consistent quality from specialized manufacturers are fundamental to the success of Idelalisib production worldwide.