The intricate world of chemistry offers powerful tools to combat threats to human health, including pervasive fungal infections. At the molecular level, the development of effective antifungal drugs relies on the precise synthesis of complex organic compounds. One such vital component in this chemical arsenal is 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine, identified by its unique CAS number 74853-08-0.

This compound serves as a critical intermediate in the manufacturing process of Posaconazole, a second-generation triazole antifungal agent. Posaconazole's strength lies in its ability to disrupt the fungal cell membrane by inhibiting the enzyme 14α-demethylase, which is responsible for converting lanosterol to ergosterol. Ergosterol is an essential component of fungal cell membranes, and its absence leads to increased permeability and cell death. The structural features provided by 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine are instrumental in the final drug's high affinity for this target enzyme.

The chemical industry's contribution to healthcare is profoundly evident in the production of such intermediates. The synthesis of 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine requires sophisticated chemical processes, ensuring high purity levels, often exceeding 99.0%, and accurate adherence to its specific chemical properties. These parameters are essential for the subsequent Posaconazole intermediate synthesis, guaranteeing the potency and safety of the final antifungal medication. Reliable access to this pharmaceutical building block is a key factor in the supply chain of critical medicines.

For researchers and manufacturers, a thorough understanding of the chemical properties of CAS 74853-08-0 is fundamental for optimizing synthetic routes and developing new therapeutic applications. The piperazine core, coupled with the strategically placed amino and hydroxyl groups, makes this molecule a valuable precursor in organic synthesis. The continuous innovation in chemical manufacturing aims to enhance the efficiency and sustainability of producing such essential compounds.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to advancing healthcare through the provision of high-quality chemical intermediates. By supplying compounds like 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine, we empower the pharmaceutical industry to develop and deliver life-saving antifungal treatments, contributing to global health and well-being.