Understanding the chemical foundation of O-Ethyl-N-Fmoc-D-tyrosine (CAS: 162502-65-0) is crucial for appreciating its utility in advanced scientific research. This Fmoc-protected D-amino acid derivative is a product of meticulous chemical synthesis, designed to offer specific advantages in peptide chemistry. Its typical appearance as a white to off-white powder is a testament to the purification processes employed to achieve high purity, often u226598.0%, ensuring reliable performance in sensitive applications.

The core structure of O-Ethyl-N-Fmoc-D-tyrosine involves the esterification of the hydroxyl group on the D-tyrosine side chain with an ethyl group. This modification, coupled with the N-terminal Fmoc protection, creates a versatile building block for solid-phase peptide synthesis (SPPS). The Fmoc group provides a labile protecting strategy, readily removed under mild basic conditions without affecting other sensitive functional groups within the peptide sequence. This orthogonality is vital for the stepwise assembly of complex peptides.

The synthesis of O-Ethyl-N-Fmoc-D-tyrosine typically begins with D-tyrosine, which undergoes selective O-ethylation followed by N-terminal Fmoc protection. Each step requires precise control of reaction conditions to ensure high yield and purity. For researchers who wish to buy O-Ethyl-N-Fmoc-D-tyrosine, sourcing from reputable manufacturers is key to obtaining a product that meets stringent quality standards. The chemical properties, such as solubility in common organic solvents used in SPPS, are optimized for efficient coupling reactions, contributing to higher overall synthesis success rates.

The distinct chemical properties imparted by the ethyl ether substituent can influence the conformation and intermolecular interactions of peptides synthesized with this residue. This makes O-Ethyl-N-Fmoc-D-tyrosine a valuable tool for creating peptides with unique structural features for applications ranging from drug discovery to proteomics. By understanding its synthesis and chemical characteristics, scientists can better leverage this essential amino acid derivative in their experimental designs.