In the intricate world of peptide synthesis, the selection of appropriate building blocks is paramount to achieving successful and efficient outcomes. N-Fmoc-3-(2-naphthyl)-L-alanine, identified by its CAS number 112883-43-9, stands out as a critical intermediate for researchers and manufacturers engaged in advanced organic chemical synthesis. This specialized amino acid derivative offers unique advantages, particularly within the framework of solid-phase peptide synthesis (SPPS).

The inherent utility of N-Fmoc-3-(2-naphthyl)-L-alanine lies in its Fmoc (9-fluorenylmethoxycarbonyl) protection. This protection strategy is a cornerstone of modern SPPS, allowing for the sequential addition of amino acids to a growing peptide chain attached to a solid support. The Fmoc group is designed to be acid-labile, meaning it can be selectively removed using mild basic conditions, typically a piperidine solution. This selective deprotection is crucial as it prevents damage to the acid-sensitive peptide-resin linker or other acid-labile protecting groups that might be present on the amino acid side chains. By employing this method, chemists can confidently build complex peptide sequences with high purity and yield.

The specific chemical structure of N-Fmoc-3-(2-naphthyl)-L-alanine, featuring a naphthyl side chain, contributes to its distinct properties. Its white to off-white powder appearance is standard for many such organic compounds. Furthermore, its solubility characteristics, being sparingly soluble in DMF and slightly soluble in DMSO and methanol, are important considerations for reaction setup and processing. These properties are well-documented and available for review by those looking to purchase this vital chemical synthesis intermediate.

Beyond its primary role in peptide synthesis, N-Fmoc-3-(2-naphthyl)-L-alanine has garnered attention for its potential in other scientific domains. Studies have indicated that this compound and related peptides may exhibit an inhibitory effect on Staphylococcus virulence. This finding opens up exciting possibilities for its application in antimicrobial research, potentially contributing to the development of new strategies to combat bacterial infections, particularly those caused by resistant strains. Researchers interested in exploring these antimicrobial applications can source this compound to investigate its therapeutic potential.

Moreover, the compound’s high fluorescent activity makes it a valuable tool in analytical chemistry. This characteristic is particularly advantageous when using techniques like High-Performance Liquid Chromatography (HPLC). The fluorescence allows for sensitive detection and accurate quantification of the compound itself or peptides synthesized using it, ensuring the quality and integrity of research materials and final products. For those seeking reliable chemical reagents for detailed analysis, N-Fmoc-3-(2-naphthyl)-L-alanine is an excellent choice.

At NINGBO INNO PHARMCHEM CO.,LTD., we are committed to providing high-quality chemical synthesis building blocks to support groundbreaking research and industrial production. Our extensive catalog includes essential intermediates like N-Fmoc-3-(2-naphthyl)-L-alanine, enabling researchers to push the boundaries in drug discovery, biotechnology, and material science. We understand the importance of consistent quality and reliable supply, ensuring that our clients have the resources they need for their most demanding projects. Explore our offerings to find the perfect chemical synthesis intermediate for your needs, and take advantage of our expertise in sourcing and supplying critical compounds.