The development of novel therapeutics like Rimegepant, a significant advancement in migraine treatment, hinges on the efficient and reliable synthesis of its key intermediates. At Ningbo Inno Pharmchem Co., Ltd., we understand that the journey from laboratory discovery to commercial availability is paved with meticulous process development. Our commitment lies in ensuring the highest quality and scalability for critical pharmaceutical building blocks.

A prime example of our dedication is the synthesis of the Rimegepant intermediate. The original synthetic routes, while effective, often presented challenges in terms of scalability, cost-effectiveness, and enantiomeric purity. To address these, we have invested heavily in optimizing the core chemical transformations. Our focus has been on leveraging cutting-edge catalytic technologies to achieve superior results.

Central to our optimized process is the implementation of a Ruthenium-catalyzed asymmetric transfer hydrogenation (ATH) reaction. This sophisticated methodology allows for the precise stereochemical control required for Rimegepant's efficacy. By carefully screening catalysts, bases, solvents, and hydrogen donors, our research team identified a combination – specifically, CAT05 catalyst, DIPEA base, dichloromethane solvent, and formic acid as the hydrogen source – that delivers exceptional outcomes. This tailored approach yields the desired Rimegepant intermediate with an impressive 92.1% yield, exceeding 99.8% purity, and a remarkable 99.9% enantiomeric excess (ee). This level of precision is paramount for pharmaceutical applications.

The scalability of our processes is a cornerstone of our service. We have successfully scaled up this Rimegepant intermediate synthesis to the kilogram level, demonstrating its robustness and readiness for commercial production. This is not merely about increasing batch sizes; it involves ensuring consistent quality, safety, and efficiency at every stage. The cost-effectiveness achieved through this optimized route also translates into tangible benefits for our clients, making high-quality intermediates more accessible.

Ningbo Inno Pharmchem Co., Ltd. is proud to be at the forefront of pharmaceutical intermediate manufacturing. Our expertise in process optimization for Rimegepant intermediate synthesis, combined with our rigorous quality control, ensures that we provide the building blocks necessary for life-changing medications. We are committed to supporting the pharmaceutical industry with reliable and high-purity intermediates, contributing to the advancement of healthcare worldwide. For inquiries regarding the purchase of Rimegepant intermediates or to discuss custom synthesis needs, our team is ready to assist.