In the dynamic field of pharmaceutical research and development, the identification and utilization of key chemical intermediates are paramount to synthesizing life-saving medications. Among these critical building blocks, 1H-Pyrrolo[2,3-b]pyridin-5-ol stands out. This heterocyclic compound, identified by its CAS number 98549-88-3, has emerged as an indispensable component in the creation of sophisticated pharmaceutical agents, most notably in the realm of oncology.

The significance of 1H-Pyrrolo[2,3-b]pyridin-5-ol lies in its unique molecular structure, which combines a pyrrole ring fused with a pyridine ring, featuring a hydroxyl group at the 5th position. This arrangement endows it with specific reactivity, making it an ideal precursor for complex drug molecules. Its molecular formula is C7H6N2O, with a molecular weight of approximately 134.14 g/mol, and it typically presents as a light yellow solid with a melting point of 219-220°C. These physicochemical properties are well-documented, providing researchers with reliable data for its application.

One of the most prominent applications of this compound is its role as a crucial intermediate in the synthesis of Venetoclax (ABT-199). Venetoclax is a highly effective and selective BCL-2 inhibitor used in the treatment of certain types of leukemia and lymphoma. The synthesis of such a targeted therapy requires precisely engineered intermediates, and 1H-Pyrrolo[2,3-b]pyridin-5-ol fits this requirement perfectly. Its structural features allow for specific functionalization steps that are essential to building the final Venetoclax molecule.

Beyond its established role in Venetoclax synthesis, 1H-Pyrrolo[2,3-b]pyridin-5-ol is also a key precursor for developing potent VEGFR-2 inhibitors. Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) is a critical target in cancer therapy, as it plays a vital role in angiogenesis – the formation of new blood vessels that tumors need to grow and spread. Inhibiting VEGFR-2 can therefore starve tumors of nutrients and oxygen. The compound's versatility in organic synthesis allows medicinal chemists to design and synthesize novel VEGFR-2 inhibitors with improved efficacy and reduced side effects.

The importance of 1H-Pyrrolo[2,3-b]pyridin-5-ol is further underscored by its broader application as a heterocyclic compound for pharmaceuticals. Its presence in the synthetic routes of various drug candidates highlights its adaptability and value in medicinal chemistry. Researchers are continually exploring its potential in developing treatments for a wide range of diseases, leveraging its unique chemical properties to create novel therapeutic agents.

NINGBO INNO PHARMCHEM CO.,LTD. is a prominent supplier of this essential intermediate, ensuring its availability for research and industrial applications. By providing high-quality 1H-Pyrrolo[2,3-b]pyridin-5-ol, companies like NINGBO INNO PHARMCHEM CO.,LTD. support the vital work of scientists and drug developers. The competitive pricing and reliable supply of such compounds are critical factors in accelerating the pace of drug discovery and bringing new treatments to patients. The ongoing demand for this versatile intermediate reflects its sustained importance in advancing the frontiers of pharmaceutical science.

In conclusion, 1H-Pyrrolo[2,3-b]pyridin-5-ol is more than just a chemical compound; it is a gateway to innovative therapies. Its role as a key intermediate in the synthesis of advanced cancer drugs like Venetoclax and in the development of VEGFR-2 inhibitors demonstrates its profound impact on modern medicine. As research continues, the utility of this heterocyclic compound for pharmaceuticals is only expected to grow, cementing its position as a cornerstone of pharmaceutical synthesis.