The journey from a concept in medicinal chemistry to a finished pharmaceutical product is a complex one, heavily reliant on the availability of precisely engineered chemical building blocks. Among these essential components is (aR)-4-Chlorophenylglycine Hydrochloride, identified by CAS 108392-76-3, a compound that plays a significant role in modern drug synthesis.

This chemical, with the systematic name Benzeneacetic acid, a-amino-4-chloro-, hydrochloride(1:1),( 57187535,aR)-, is a chiral alpha-amino acid derivative. Its structure features a phenyl ring substituted with a chlorine atom, an alpha-amino group, and presented as a hydrochloride salt. The specified (aR) configuration is of paramount importance, as it dictates the stereochemistry of the final drug molecule, directly influencing its therapeutic efficacy and interaction with biological targets. The compound's typical presentation as a white powder with high purity (≥99%) ensures its suitability for sensitive pharmaceutical applications.

As a building block, (aR)-4-Chlorophenylglycine Hydrochloride offers medicinal chemists a ready-made chiral center and functional groups that can be readily manipulated. The amino group can undergo acylation, alkylation, or peptide coupling reactions, while the carboxylic acid group can be esterified or amidated. The presence of the chlorine atom on the phenyl ring also provides a site for potential nucleophilic aromatic substitution or cross-coupling reactions, allowing for further structural diversification.

The demand for such chiral building blocks is driven by the pharmaceutical industry's continuous quest for more selective and potent drugs. Many biological processes are stereospecific, meaning that only one enantiomer of a drug molecule will exhibit the desired pharmacological activity. Therefore, the ability to buy alpha-amino-4-chloro-benzeneacetic acid hydrochloride in its pure (aR) form is critical for the efficient and stereoselective synthesis of chiral APIs. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. are key suppliers, providing this essential component to researchers and drug manufacturers worldwide.

The versatility of this chloro-benzeneacetic acid derivative extends to its use in creating peptidomimetics, which are compounds that mimic the structure and function of peptides but often have improved stability and bioavailability. Furthermore, its incorporation into drug candidates can influence pharmacokinetic properties such as absorption, distribution, metabolism, and excretion (ADME). The strategic use of (R)-4-chlorophenylglycine hydrochloride as a building block allows for the precise tailoring of molecular properties to optimize drug performance.

In conclusion, (aR)-4-Chlorophenylglycine Hydrochloride is more than just a chemical intermediate; it is a fundamental tool that empowers medicinal chemists and pharmaceutical manufacturers to construct complex, therapeutically relevant molecules. Its specific chiral nature and functional group versatility make it an invaluable component in the ongoing innovation and development of new pharmaceuticals.