NINGBO INNO PHARMCHEM CO.,LTD. is a leading supplier of specialized chemicals that drive innovation in research and development. N-Methyl-L-Alanine (CAS 600-21-5) is one such compound, valued for its versatile applications in chemical synthesis and biological studies. This article outlines its synthesis routes and key applications.

The synthesis of N-Methyl-L-Alanine can be achieved through several established chemical methodologies. A classical approach involves the nucleophilic substitution of α-halogenated propionic acids, such as α-bromopropionic acid, with methylamine. This SN2 reaction, when carried out with a sufficient excess of methylamine, yields the desired product. Alternatively, N-methylation of alanine itself can be performed using methylating agents in the presence of a base. More advanced routes include biocatalytic production using engineered microorganisms, offering a greener alternative. NINGBO INNO PHARMCHEM CO.,LTD. offers N-Methyl-L-Alanine that adheres to stringent quality standards, ensuring high purity for all research applications.

The applications of N-Methyl-L-Alanine are diverse and impactful. In peptide chemistry, it is extensively used to create peptide analogues with enhanced stability against proteolytic degradation. By incorporating N-methylated residues, peptides exhibit increased resistance to enzymatic cleavage, a crucial factor for developing stable and effective peptide-based therapeutics. NINGBO INNO PHARMCHEM CO.,LTD. supports these advancements by providing reliable N-Methyl-L-Alanine for custom peptide synthesis.

Beyond peptide synthesis, N-Methyl-L-Alanine is a valuable tool in biochemical assays. It serves as a standard for studying amino acid transport systems, helping researchers understand cellular uptake mechanisms. Its unique structure also makes it a useful component in the de novo design of peptide conformations, allowing for the creation of peptides with specific shapes and functionalities. Furthermore, recent metabolomic studies have identified N-Methyl-L-Alanine as a potential biomarker for conditions like migraine, highlighting its importance in neurological research.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to facilitating cutting-edge research by providing high-quality N-Methyl-L-Alanine and supporting its diverse applications. Whether for peptide synthesis, biochemical assays, or biomarker discovery, this modified amino acid remains a critical component in scientific advancement.