For chemists and researchers engaged in organic synthesis and material science, a thorough understanding of the properties of key intermediates is paramount. 3-Fluoro-2-methylaniline, with its CAS number 443-86-7, is one such compound whose specific chemical and physical characteristics dictate its utility and potential applications. This article aims to provide an in-depth look at these properties, shedding light on why this fluorinated aromatic amine is a valuable reagent for advanced research and development.

Chemically, 3-Fluoro-2-methylaniline is classified as a substituted aniline. Its molecular formula, C7H8FN, and molecular weight of approximately 125.14 g/mol, are fundamental identifiers. The molecule features an amine (-NH2) group attached to a benzene ring, which also carries a fluorine atom and a methyl group (-CH3) at specific positions. The amine group is nucleophilic and can readily participate in reactions such as acylation, sulfonylation, and alkylation, forming amide, sulfonamide, and secondary/tertiary amine derivatives, respectively. These reactions are foundational in creating more complex organic structures. The presence of the fluorine atom, an electron-withdrawing group, influences the electron density of the aromatic ring, potentially affecting its reactivity in electrophilic aromatic substitution reactions. This nuanced reactivity makes 3-Fluoro-2-methylaniline a versatile tool in fine chemical synthesis.

Physically, 3-Fluoro-2-methylaniline is typically described as a light yellow transparent liquid. Its boiling point is noted as 89-91 °C at 15 mmHg, indicating it is relatively volatile under reduced pressure but requires elevated temperatures at atmospheric pressure. The melting point is around 7 °C, meaning it exists as a liquid under standard laboratory conditions. The flash point of 86 °C signifies that it is a combustible liquid and requires appropriate handling precautions. The refractive index, measured between 1.542-1.544, is a useful parameter for identification and quality control. Its density is reported as approximately 1.099 g/cm³.

Stability is another critical property for any chemical intermediate. 3-Fluoro-2-methylaniline is generally considered stable under normal temperatures and pressures. However, like many amines, it can be sensitive to oxidation and prolonged exposure to air or light. Therefore, proper storage conditions are essential to maintain its purity and reactivity. Recommendations typically include storing it in a cool, dry, well-ventilated place in a tightly sealed container, away from incompatible materials such as strong oxidizing agents and acids. This ensures its integrity for precise organic synthesis workflows.

Researchers often need to purchase 3-Fluoro-2-methylaniline for specific synthetic targets. Understanding these properties helps in designing reaction conditions, selecting appropriate solvents, and implementing safe handling and storage protocols. The detailed specifications, such as purity levels (often ≥98.0%), are crucial for ensuring the reproducibility and success of experimental outcomes. NINGBO INNO PHARMCHEM CO.,LTD. provides these detailed specifications to support the scientific community.

In conclusion, the chemical and physical properties of 3-Fluoro-2-methylaniline make it a valuable and versatile intermediate for a wide range of research and development activities. Its predictable reactivity, combined with its stability when stored correctly, allows chemists to leverage its structure for creating novel compounds for pharmaceuticals, agrochemicals, and advanced materials. A deep understanding of these attributes is the first step towards unlocking its full potential in innovative chemical synthesis.