NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing researchers with comprehensive information about the chemical building blocks we supply. Fmoc-2-chloro-L-phenylalanine, a key intermediate in organic synthesis, possesses a distinct set of Fmoc-2-chloro-L-phenylalanine chemical properties that are critical for its successful application in diverse scientific fields, particularly in peptide synthesis and medicinal chemistry.

With the CAS number 198560-41-7, Fmoc-2-chloro-L-phenylalanine is characterized by its molecular formula C24H20ClNO4 and a molecular weight of approximately 421.9 g/mol. It typically presents as a white powder, signifying a high degree of purity that is essential for sensitive chemical reactions. The Fmoc group (9-fluorenylmethoxycarbonyl) is the defining feature, providing base-labile protection to the amino group. This protection strategy is fundamental to the stepwise elongation of peptide chains in solid-phase synthesis, allowing for controlled coupling reactions without unwanted side reactions at the N-terminus.

The phenyl ring of the phenylalanine residue is substituted with a chlorine atom at the ortho position. This seemingly small modification can significantly impact the overall properties of the molecule and the peptides it forms. The electronegativity of the chlorine atom can alter the electron distribution within the phenyl ring, potentially influencing pi-pi stacking interactions and hydrophobic contributions in peptide tertiary structures. Furthermore, the chlorine atom can serve as a reactive site for further functionalization or can influence the metabolic stability of derived peptides, a key consideration in Fmoc-2-chloro-L-phenylalanine drug development.

Researchers looking to buy Fmoc-2-chloro-L-phenylalanine should always inquire about its purity and characterization data. High Fmoc-2-chloro-L-phenylalanine purity ensures that the intended reactions proceed efficiently and that the resulting products are free from impurities that could compromise experimental outcomes or therapeutic efficacy. The consistent quality offered by NINGBO INNO PHARMCHEM CO.,LTD. ensures that scientists can rely on this compound for demanding applications, including complex Fmoc-2-chloro-L-phenylalanine peptide synthesis and specialized biochemical assays.

The solubility and stability of Fmoc-2-chloro-L-phenylalanine are also important chemical properties to consider. While generally soluble in organic solvents commonly used in peptide synthesis, such as DMF and NMP, understanding its specific solubility profile is crucial for preparing reaction solutions and stock materials. Its stability under standard laboratory conditions, particularly with respect to the Fmoc group's sensitivity to bases, is well-established, making it a reliable choice for researchers.