Benzyl (2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride, identified by CAS number 87269-87-2, is a complex organic molecule that serves as a cornerstone in the production of Ramipril. This article delves into its essential chemical characteristics, manufacturing considerations, and the stringent quality assurance processes that ensure its suitability for pharmaceutical applications.

With a molecular formula of C₁₅H₂₀ClNO₂ and a molecular weight of approximately 281.78 g/mol, this compound presents as a white or off-white crystalline powder. Its physical properties, such as a melting range of 176-180°C and a flash point of 190°C, indicate good thermal stability, which is crucial for safe handling and processing. The specific rotation, typically between -38.5° and -42°, confirms its chiral nature and the critical stereochemical configuration essential for its function as a Ramipril intermediate.

The synthesis of Benzyl (2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride involves sophisticated multi-step organic reactions. Manufacturers often employ advanced techniques to ensure the correct stereochemistry is maintained throughout the process. This includes meticulous control over reaction conditions, the use of chiral catalysts or auxiliaries, and rigorous purification methods such as crystallization and chromatography. The goal is to achieve exceptionally high purity levels, with total impurities typically kept below 0.5% and loss on drying not exceeding 0.5%.

At NINGBO INNO PHARMCHEM CO.,LTD., we are dedicated to mastering these synthesis challenges. Our expertise in producing this key Ramipril intermediate involves a deep understanding of reaction kinetics, solvent selection, and advanced analytical techniques like High-Performance Liquid Chromatography (HPLC) and Nuclear Magnetic Resonance (NMR) spectroscopy for quality verification. We understand that the price of our Benzyl (2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride reflects not just the raw materials but also the extensive research, development, and quality control invested. This commitment ensures that our clients receive a product that significantly contributes to the reliability and success of their Ramipril manufacturing processes. When you purchase this compound, you are acquiring a precisely engineered molecule that underpins the quality of a vital pharmaceutical.