In the realm of industrial chemistry, a thorough understanding of a compound's properties and safe handling procedures is paramount. 1,3-Dichloroacetone (CAS 534-07-6) is one such chemical, widely recognized for its utility as a synthetic intermediate but also known for its hazardous characteristics. A comprehensive grasp of its physical and chemical attributes, alongside stringent safety protocols, is crucial for its effective and safe utilization.

Physically, 1,3-Dichloroacetone presents as a white crystalline solid. Its molecular formula is C3H4Cl2O, and it has a molecular weight of approximately 126.97 g/mol. Key physical properties include a melting point typically in the range of 38-42°C and a boiling point around 172-173°C. Its density is reported at approximately 1.383 g/cm³. These characteristics are important for determining appropriate storage conditions and handling methods.

Chemically, the presence of two chlorine atoms bonded to the carbonyl carbon makes 1,3-Dichloroacetone highly reactive. This reactivity underpins its value as an intermediate in various organic synthesis pathways. It readily participates in nucleophilic substitution and addition reactions, making it a versatile building block for complex molecules used in pharmaceuticals, agrochemicals, and specialty chemicals.

However, the utility of 1,3-dichloroacetone comes with significant safety considerations. It is classified as a hazardous substance, known to be toxic and corrosive. Exposure can cause severe irritation to the skin, eyes, and respiratory system. Fatalities can occur if swallowed, inhaled, or absorbed through the skin. Therefore, strict adherence to safety guidelines is non-negotiable. This includes the mandatory use of appropriate personal protective equipment (PPE) such as chemical-resistant gloves, safety goggles or face shields, and protective clothing. Adequate ventilation, preferably in a fume hood, is essential to minimize inhalation exposure.

Storage of 1,3-dichloroacetone requires careful attention. It should be kept in tightly closed containers, stored in a cool, dry, and well-ventilated area, away from incompatible materials such as strong oxidizing agents, bases, and reducing agents. Proper labeling and hazard communication are also critical components of safe storage and handling practices.

Companies involved in the chemical industry, whether for research or large-scale production, must prioritize training for personnel handling 1,3-dichloroacetone. Understanding the Material Safety Data Sheet (MSDS) is a fundamental step in this training. Sourcing from reliable suppliers, who provide high-purity products and detailed technical and safety documentation, further enhances the safety and efficiency of its use.

In conclusion, 1,3-Dichloroacetone is a valuable chemical intermediate with significant industrial applications. By understanding its properties and rigorously implementing safety protocols, industries can effectively harness its chemical potential while ensuring the well-being of their workforce and the environment.

Ningbo Inno Pharmchem Co., Ltd. is dedicated to providing high-quality 1,3-dichloroacetone, accompanied by comprehensive safety information to support its responsible use in industrial and research settings.