For professionals in the pharmaceutical industry, a thorough understanding of the chemical profiles of intermediates is crucial for successful drug development and manufacturing. Boc-L-2-aminobutyric acid (CAS 34306-42-8) is one such intermediate, valued for its specific chemical characteristics that make it an essential component in the synthesis of vital medications, notably Idelalisib.

The chemical identity of Boc-L-2-aminobutyric acid is rooted in its structure: it is the N-protected form of the amino acid L-2-aminobutyric acid. The tert-butoxycarbonyl (Boc) group is attached to the amine nitrogen, serving as a protecting group. This protection is vital in multi-step organic synthesis, preventing the amine from participating in unwanted reactions while other functional groups are modified. The chemical name (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid precisely describes this structure, highlighting the 'L' or 'S' configuration at the alpha-carbon, which is critical for its biological relevance in downstream applications.

From a physical properties standpoint, Boc-L-2-aminobutyric acid typically presents as a white to off-white powder. Its melting point, usually specified in the range of 61-68°C, is an important indicator of its purity. High-purity material will melt within a narrow temperature range. Furthermore, its assay, a measure of the percentage of the desired compound present, is typically specified as u226598.5%. This high purity is non-negotiable for pharmaceutical intermediates, as even minor impurities can have significant consequences in the complex reaction sequences leading to APIs.

The primary application driving the demand for Boc-L-2-aminobutyric acid is its role as a key intermediate in the synthesis of Idelalisib. The development of Idelalisib, a targeted therapy for certain B-cell malignancies, involves sophisticated chemical transformations where the precise incorporation of the Boc-L-2-aminobutyric acid moiety is essential for building the final drug molecule. The chiral integrity of the intermediate is paramount for the drug's efficacy and safety.

When considering the buy/purchase of such chemicals, manufacturers often emphasize their capabilities in producing these intermediates to exacting standards. Suppliers, particularly those in China, often provide detailed specifications and certificates of analysis for their products. This transparency ensures that researchers and production managers can have confidence in the material they are using. The consistent availability of high-quality Boc-L-2-aminobutyric acid is a critical factor in the reliable production of Idelalisib and other potential pharmaceuticals that utilize this valuable chiral building block.

In essence, understanding the detailed chemical profile of Boc-L-2-aminobutyric acid—from its molecular structure and protecting group chemistry to its physical properties and assay specifications—is fundamental to its successful application in the demanding field of pharmaceutical manufacturing.