For chemists and material scientists, a deep understanding of chemical intermediates is crucial for successful synthesis and product development. 4'-Nitro-[1,1'-biphenyl]-4-ol, identified by CAS number 3916-44-7, is a compound that warrants close examination due to its unique chemical structure and broad applicability. NINGBO INNO PHARMCHEM CO.,LTD., as a leading provider of fine chemicals and pharmaceutical intermediates, offers insights into the properties and synthesis of this important compound.

The molecular formula of 4'-Nitro-[1,1'-biphenyl]-4-ol is C12H9NO3, with a molecular weight of approximately 215.20 g/mol. The structure consists of two phenyl rings connected by a single bond, forming the biphenyl moiety. Attached to this core structure are a nitro group (-NO2) and a hydroxyl group (-OH). The positioning of these functional groups, specifically the nitro group at the 4'-position and the hydroxyl group at the 4-position, dictates its reactivity and utility. Typically, it appears as a yellow to light brown crystalline powder. Its melting point is reported to be around 198–202°C, indicating it is a solid at room temperature. While it has low solubility in water, it readily dissolves in common organic solvents like ethanol, acetone, and DMSO, which is a significant advantage for many synthesis procedures.

The chemical properties of 4'-Nitro-[1,1'-biphenyl]-4-ol are largely influenced by its functional groups. The hydroxyl group can participate in etherification, esterification, and other reactions characteristic of phenols. The nitro group, on the other hand, can be reduced to an amine, which opens up further synthetic possibilities, such as amide formation or diazotization. This dual functionality makes it an excellent intermediate for building more complex molecules. As a trusted chemical synthesis starting material, it enables chemists to perform a variety of transformations efficiently.

Regarding synthesis, common methods for preparing 4'-Nitro-[1,1'-biphenyl]-4-ol often involve coupling reactions. One prevalent approach is the Suzuki coupling reaction, which can couple a boronic acid or boronate ester with an aryl halide. For example, a route might involve coupling 4-hydroxyphenylboronic acid (or its pinacol ester) with 1-bromo-4-nitrobenzene or a similar nitro-substituted aryl halide. These reactions are typically catalyzed by palladium complexes and require specific reaction conditions, including solvents and bases, to achieve good yields and purity. NINGBO INNO PHARMCHEM CO.,LTD.’s expertise in complex organic synthesis allows us to produce this compound with high fidelity.

For those seeking to buy 4-Hydroxy-4'-nitrobiphenyl, understanding these chemical properties and synthesis routes is beneficial. It helps in selecting the appropriate grade of the chemical and anticipating its behavior in specific reactions. NINGBO INNO PHARMCHEM CO.,LTD., as a premier pharmaceutical intermediate manufacturer and organic intermediate supplier in China, ensures that our product adheres to strict quality control measures, guaranteeing its suitability for a wide range of chemical applications, from research laboratories to industrial manufacturing.

In conclusion, 4'-Nitro-[1,1'-biphenyl]-4-ol (CAS 3916-44-7) is a compound of significant chemical interest, characterized by its biphenyl structure, nitro and hydroxyl functional groups, and versatile reactivity. Its well-defined properties and accessibility through established synthetic routes make it an invaluable intermediate for numerous chemical industries. NINGBO INNO PHARMCHEM CO.,LTD. is proud to supply this essential chemical, supporting advancements in chemical synthesis worldwide.