The chemical industry constantly seeks robust and reliable intermediates to drive innovation and production. Among these, 4-(Chloromethyl)tolunitrile, bearing the CAS number 874-86-2, has established itself as a compound of significant importance. This article, brought to you by NINGBO INNO PHARMCHEM CO.,LTD., aims to provide a detailed understanding of its synthesis, key applications, and the critical quality parameters that govern its use.

The synthesis of 4-(Chloromethyl)tolunitrile typically involves the chloromethylation of p-tolunitrile. This process requires careful control of reaction conditions to ensure high yields and minimize the formation of by-products. The resulting compound is a white crystalline solid with a melting point in the range of 77-79°C. Its chemical structure, featuring a nitrile group and a chloromethyl group on a benzene ring, endows it with versatile reactivity, making it a sought-after intermediate in various synthetic pathways.

As a pivotal pyrimethamine intermediate, 4-(Chloromethyl)tolunitrile is indispensable in the pharmaceutical industry. Pyrimethamine, an antifolate drug, is crucial for treating and preventing infections like malaria and toxoplasmosis. The purity and consistent quality of the pyrimethamine intermediate are paramount for the efficacy and safety of the final drug product. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supplying this intermediate with the utmost purity, supporting pharmaceutical companies in their mission to produce reliable medications.

Another significant application of 4-(Chloromethyl)tolunitrile is in the manufacturing of fluorescent whitening agents (FWAs). These additives are widely used to enhance the perceived brightness of materials such as textiles, paper, and plastics. The specific chemical properties of 4-(Chloromethyl)tolunitrile as a precursor allow for the creation of FWAs that efficiently convert UV light into visible blue light, making materials appear whiter and more vibrant. Manufacturers seeking to buy 4-(Chloromethyl)tolunitrile for FWA production can rely on NINGBO INNO PHARMCHEM CO.,LTD. for consistent product quality.

The quality specifications for 4-(Chloromethyl)tolunitrile are rigorous, often requiring purity levels of 99.0% or higher, low volatile content, and adherence to specific melting point ranges. These parameters are essential for ensuring predictable reaction outcomes and the integrity of the end products. NINGBO INNO PHARMCHEM CO.,LTD. places a strong emphasis on quality control, providing batch-specific COAs to guarantee that their 4-(Chloromethyl)tolunitrile meets the highest industry standards.

In summary, 4-(Chloromethyl)tolunitrile (CAS 874-86-2) is a foundational chemical intermediate with far-reaching applications in pharmaceuticals and the production of fluorescent whitening agents. Its reliable synthesis and high-purity supply are critical for advancing chemical manufacturing. NINGBO INNO PHARMCHEM CO.,LTD. is a trusted partner for businesses requiring this essential compound, ensuring quality and consistency for all their synthetic needs.