Introduction to 2-Bromovaleric Acid
2-Bromovaleric Acid, also known as α-Bromovaleric Acid, is a chemical compound with the CAS number 584-93-0. This compound is a clear pale yellow liquid with a molecular formula of C5H9BrO2 and a molecular weight of 181.03 g/mol. It is widely used in the synthesis of various pharmaceuticals and fine chemicals due to its unique chemical properties.
Chemical Properties and Physical Characteristics
2-Bromovaleric Acid exhibits several notable physical and chemical properties that make it valuable in various applications. It has a melting point of 252°C (sublimation), a boiling point of 132-136°C at 25 mmHg, and a density of 1.381 g/mL at 25°C. The refractive index is n20/D 1.4709, and its flash point is greater than 230°F. The pKa value is predicted to be 2.97±0.20, indicating its acidic nature. These properties make 2-Bromovaleric Acid suitable for a range of chemical reactions and processes.
Synthesis of 2-Bromovaleric Acid
The synthesis of 2-Bromovaleric Acid typically involves the bromination of valeric acid. One common method uses bromine and phosphorus trichloride as reagents, with the reaction taking place over 4.5 hours at elevated temperatures, yielding up to 91% of the product. Another method employs N-Bromosuccinimide (NBS) and sulfuric acid in trifluoroacetic acid at 85°C for 16 hours, achieving an 86% yield. These synthesis routes highlight the versatility and efficiency of producing 2-Bromovaleric Acid for industrial applications.
Applications in Pharmaceuticals and Fine Chemicals
2-Bromovaleric Acid is a crucial intermediate in the synthesis of various pharmaceuticals. It has been used in the solid-phase synthesis of 2,4,5-trisubstituted thiomorpholine-3-ones, demonstrating its utility in creating complex molecular structures. Additionally, it serves as a building block in the production of other fine chemicals, such as 2-bromo-pentanoic acid (2-methyl-4-nitro-phenyl)-amide, which is synthesized using phosphorus trichloride in benzene. These applications underscore the importance of 2-Bromovaleric Acid in the chemical industry.
Safety and Handling
Handling 2-Bromovaleric Acid requires strict adherence to safety protocols due to its hazardous nature. It is classified as toxic by inhalation, in contact with skin, and if swallowed, and can cause burns. It is essential to wear suitable protective clothing, gloves, and eye/face protection when working with this chemical. In case of contact with eyes, immediate rinsing with plenty of water and seeking medical advice is necessary. These safety measures ensure the well-being of those working with 2-Bromovaleric Acid.
2-Bromovaleric Acid Manufacturer in China
NINGBO INNO PHARMCHEM CO.,LTD. is a leading
2-Bromovaleric Acid manufacturer in China, dedicated to providing high-quality chemical products. Our expertise in the synthesis and production of 2-Bromovaleric Acid ensures that our clients receive reliable and consistent supplies of this essential compound. We are committed to maintaining the highest standards of quality and safety in our manufacturing processes.
2-Bromovaleric Acid Supplier in China
As a premier
2-Bromovaleric Acid supplier in China, NINGBO INNO PHARMCHEM CO.,LTD. offers comprehensive solutions for the procurement of this chemical. Our extensive distribution network ensures timely delivery and competitive pricing, making us a trusted partner for businesses worldwide. We are dedicated to meeting the diverse needs of our clients and providing exceptional customer service.
Other Services Offered by NINGBO INNO PHARMCHEM CO.,LTD.
In addition to our expertise in 2-Bromovaleric Acid, NINGBO INNO PHARMCHEM CO.,LTD. offers a wide range of services in the field of fine chemicals and pharmaceutical intermediates. Our main business areas include the research and development, production, and manufacturing of fine chemicals and pharmaceutical intermediates. We specialize in continuous flow process development and equipment manufacturing, with our own pilot plant and external large-scale production platforms. Our expertise covers various reaction types, including high-temperature, high-pressure, nitration, oxidation, and continuous distillation processes.
Our R&D and manufacturing services encompass a broad spectrum of compounds, including bromides, boric acids, thiophenes, indoles, imidazoles, thiazoles, piperazines, and pyrazines. We focus on products with volumes ranging from 100 kg to 100 MT per year, with up to 5 synthetic steps. If you have any other needs, please feel free to contact us.
