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Bis(2-dimethylaminoethyl)ether: A Comprehensive Overview
Publish Date:2025-05-28      Click:212

Introduction to Bis(2-dimethylaminoethyl)ether

Bis(2-dimethylaminoethyl)ether, also known by its CAS number 3033-62-3, is a chemical compound with a variety of applications in the chemical and pharmaceutical industries. Commonly referred to by its aliases such as 2,2'-Oxybis(N,N-dimethylethanamine), A 99, and BDMAEE, this compound is a clear or yellow liquid with a boiling point of 188°C. It is highly toxic and can be harmful through inhalation, skin absorption, ingestion, and eye contact. This article delves into the properties, uses, and safety considerations of Bis(2-dimethylaminoethyl)ether, highlighting its significance as a key component in various industrial processes.

Chemical Properties and Structure

Bis(2-dimethylaminoethyl)ether, with the molecular formula C8H20N2O, has a molecular weight of 160.26 g/mol. It is a tertiary amine that exhibits high solubility in water, with a solubility of 100g/L at 20°C. The compound's aqueous solution is alkaline, with a pKa of 9.12±0.28. Its refractive index is 1.430 at 20°C, and it has a density of 0.841 g/mL at 25°C. The chemical structure of Bis(2-dimethylaminoethyl)ether consists of two dimethylaminoethyl groups connected by an ether linkage, which contributes to its unique chemical behavior and reactivity.

Applications in Industry

Bis(2-dimethylaminoethyl)ether is widely recognized for its role as an efficient tertiary amine catalyst in the production of polyurethane foams. It is particularly effective in the manufacturing of flexible foam products, including high resilience and RIM (Reaction Injection Molding) products. The compound's high catalytic activity and selectivity for the foaming reaction make it an essential component in achieving stable foaming and enhancing the physical and chemical properties of the final products, such as resilience and elongation. Additionally, Bis(2-dimethylaminoethyl)ether is used in the synthesis of various pharmaceuticals and as a solvent in certain chemical processes.

Safety and Handling

Due to its toxic nature, handling Bis(2-dimethylaminoethyl)ether requires strict safety measures. It is classified as a highly flammable and corrosive substance, with the potential to form explosive peroxides upon exposure to air. The recommended safety protocols include wearing appropriate protective clothing, ensuring thorough ventilation in work areas, and avoiding contact with skin and eyes. In case of exposure, immediate medical attention is necessary. Storage should be in a cool, dry, and well-ventilated area, away from heat sources and oxidizing agents.

Regulatory and Environmental Considerations

Bis(2-dimethylaminoethyl)ether is subject to various regulatory standards due to its hazardous properties. It is listed under the TSCA (Toxic Substances Control Act) and has specific exposure limits set by ACGIH (American Conference of Governmental Industrial Hygienists), with a TWA (Time-Weighted Average) of 0.05 ppm and a STEL (Short-Term Exposure Limit) of 0.15 ppm. Environmental considerations include proper disposal methods to prevent contamination and ensure compliance with local and international regulations.

Conclusion

Bis(2-dimethylaminoethyl)ether is a versatile chemical compound with significant applications in the production of polyurethane foams and pharmaceuticals. Its unique properties as a tertiary amine catalyst make it indispensable in achieving high-quality foam products. However, its handling requires stringent safety measures due to its toxic and flammable nature. As a leading Bis(2-dimethylaminoethyl)ether manufacturer in China, NINGBO INNO PHARMCHEM CO.,LTD. ensures the highest standards in production and safety, contributing to the advancement of various industries.

Our Other Services

At NINGBO INNO PHARMCHEM CO.,LTD., our main business scope includes the research and development, as well as the production of fine chemicals and pharmaceutical intermediates. We specialize in continuous flow process development and equipment manufacturing, with our own pilot plant and external large-scale production platforms. Our expertise covers various reaction types such as high temperature, high pressure, nitration, oxidation, and continuous distillation. Our R&D and manufacturing services encompass fine chemicals and pharmaceutical intermediates like bromide, boric acid, thiophene, indole, imidazole, thiazole, piperazine, and pyrazine compounds, with production volumes ranging from 100 kgs to 100 MT per year and up to 5 synthetic steps. As a trusted Bis(2-dimethylaminoethyl)ether supplier in China, we are committed to meeting your chemical needs. If you have any other requirements, please feel free to contact us.
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