Di(1H-indol-3-yl)methane, also known as 3,3-Diindolylmethane, is a versatile compound with significant applications in cancer research, hormonal regulation, and antimicrobial properties.
Introduction to Di(1H-indol-3-yl)methane
Di(1H-indol-3-yl)methane, commonly referred to as 3,3-Diindolylmethane (DIM), is a compound with the CAS number 1968-05-4. It is also known by other names such as 3,3-Methylenediindole and 3,3-Diindolemethane. This compound is derived from the digestion of indole-3-carbinol, which is found in cruciferous vegetables like broccoli, Brussels sprouts, and cabbage. DIM has garnered significant attention due to its potential health benefits and therapeutic properties, particularly in the fields of cancer research and hormonal regulation.
Chemical Properties and Synthesis
DIM is a white to off-white crystalline powder with a molecular formula of C17H14N2 and a molecular weight of 246.31. It has a melting point of 167°C and is soluble in solvents like chloroform and methanol. The synthesis of DIM involves the reaction of indole with formaldehyde under acidic conditions, leading to the formation of the dimeric structure. This process is crucial for understanding the compound's stability and reactivity, which are essential for its applications in various fields. As a leading
Di(1H-indol-3-yl)methane manufacturer in China, NINGBO INNO PHARMCHEM CO.,LTD. ensures the highest quality and purity of DIM through rigorous quality control processes.
Applications in Cancer Research
One of the most significant applications of Di(1H-indol-3-yl)methane is in cancer research. DIM has been extensively studied for its potential anticancer properties. It is known to induce apoptosis, inhibit cell proliferation, and modulate various signaling pathways involved in cancer development. Studies have shown that DIM can effectively inhibit the growth of various cancer cell lines, including breast, prostate, and colorectal cancers. For instance, DIM has been found to induce G1 cell cycle arrest in human breast cancer cells by increasing the expression of p21, a key regulator of cell cycle progression. This makes DIM a promising candidate for cancer prevention and treatment strategies, and as a
Di(1H-indol-3-yl)methane supplier in China, we are committed to advancing this research.
Hormonal Regulation and Health Benefits
Beyond its anticancer properties, DIM also plays a crucial role in hormonal regulation. It is known to influence estrogen metabolism by promoting the conversion of estradiol into less potent forms, which can be beneficial for hormone-dependent cancers. Additionally, DIM has been studied for its potential in alleviating symptoms associated with hormonal imbalances, such as those experienced during menopause. Clinical trials have shown that DIM supplementation can lead to favorable changes in estrogen metabolism profiles among women at risk for breast cancer, highlighting its potential as a health supplement.
Antimicrobial and Neuroprotective Effects
Recent research has also explored the antimicrobial properties of DIM. It has been found to significantly reduce biofilm formation by pathogenic bacteria such as Streptococcus mutans, suggesting its potential use in oral health and the prevention of dental caries. Furthermore, DIM has shown neuroprotective effects by enhancing the production of brain-derived neurotrophic factor (BDNF) and antioxidant enzymes, which can protect neuronal cells from oxidative stress-induced apoptosis. These findings indicate that DIM could have broader applications in health and medicine beyond cancer research.
Manufacturing and Supply in China
As a leading
Di(1H-indol-3-yl)methane manufacturer in China, NINGBO INNO PHARMCHEM CO.,LTD. ensures the highest quality and purity of DIM. Our state-of-the-art facilities and rigorous quality control processes guarantee that our products meet the stringent standards required for research and therapeutic applications. We are also a reliable
Di(1H-indol-3-yl)methane supplier in China, providing DIM to various industries and research institutions worldwide.
Conclusion
Di(1H-indol-3-yl)methane (DIM) is a multifaceted compound with significant potential in cancer research, hormonal regulation, antimicrobial applications, and neuroprotection. Its diverse biological activities make it a valuable subject for ongoing research and a promising candidate for therapeutic applications. As a
Di(1H-indol-3-yl)methane manufacturer in China, NINGBO INNO PHARMCHEM CO.,LTD. is committed to advancing the understanding and utilization of DIM through our high-quality products and services.
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Our company's main business scope includes the research and development, as well as the production of fine chemicals and pharmaceutical intermediates. We specialize in continuous flow process development and the manufacturing of continuous flow equipment. We have our own pilot plant and external cooperative large-scale production platforms. Our expertise covers various reaction types such as high temperature, high pressure, nitration, oxidation, and continuous distillation. Our R&D and manufacturing services include fine chemicals, pharmaceutical intermediates like bromide, boric acid, thiophene, indole, imidazole, thiazole, piperazine, and pyrazine compounds, from ton to hundred tons lot. We focus product Volume between 100 kgs to 100 MT per year with up to 5 synthetic steps only. If you have any other needs, please feel free to contact us.
