Acyclovir is a highly effective antiviral medication, but its efficacy hinges on proper dosage and administration. Understanding how to take acyclovir correctly ensures that the medication works optimally to combat viral infections like herpes, shingles, and chickenpox.

The dosage of acyclovir varies significantly depending on the specific viral infection being treated, the patient's age, weight, kidney function, and the severity of the condition. Healthcare professionals determine the most appropriate regimen for each individual.

For genital herpes, initial treatment typically involves taking acyclovir orally five times a day for ten days, or alternatively, three times a day for seven to ten days. To prevent recurrent outbreaks, a lower daily dosage is often prescribed for longer periods, sometimes up to twelve months. For active outbreaks, it is crucial to start acyclovir as soon as the first symptoms appear – such as tingling, itching, or burning sensations – or when the first sore is visible. Early intervention is key to minimizing the severity and duration of the outbreak.

When treating shingles, the dosage is generally higher, often involving 800 mg taken five times a day for seven to ten days. For chickenpox, especially in immunocompromised patients, specific dosing guidelines based on body weight are followed, typically administered four times a day for five days. It’s important to note that for chickenpox, the medication is most effective when started within 24 hours of the rash appearing.

Administration of oral acyclovir is usually done with a full glass of water. It can be taken with or without food, though taking it with food may help reduce gastrointestinal upset. It is critical to complete the full course of treatment as prescribed, even if symptoms improve, to ensure the virus is fully suppressed and to prevent the development of resistant strains.

For intravenous (IV) administration, typically reserved for severe infections or hospitalized patients, doses are calculated based on body weight and administered slowly over at least an hour. Dosage adjustments are often necessary for patients with impaired kidney function, as acyclovir is primarily excreted by the kidneys. Taking adequate fluids is essential to prevent dehydration and reduce the risk of kidney side effects.

When purchasing acyclovir, whether as powder for compounding or finished dosage forms, it is vital to follow the prescribed instructions precisely. Consulting with a pharmacist or healthcare provider can provide further clarification on dosage and administration, ensuring the best possible treatment outcomes.